FBXL7 explained

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.^{[1] [2] [3]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Winston JT, Koepp DM, Zhu C . A family of mammalian F-box proteins. . Curr. Biol. . 9 . 20 . 1180–2 . 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . etal. free . 1999CBio....9.1180W .
• Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C . cDNA cloning and expression analysis of new members of the mammalian F-box protein family. . Genomics . 67 . 1 . 40–7 . 2001 . 10945468 . 10.1006/geno.2000.6211 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Watanabe N, Arai H, Nishihara Y . M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 13 . 4419–24 . 2004 . 15070733 . 10.1073/pnas.0307700101 . 384762 . 2004PNAS..101.4419W . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Venables JP, Bourgeois CF, Dalgliesh C . Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. . Hum. Mol. Genet. . 14 . 16 . 2289–303 . 2005 . 16000324 . 10.1093/hmg/ddi233 . etal.

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 5 . 6 . 355–64 . May 1999 . 10048485 . 10.1093/dnares/5.6.355 . free .
2. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
3. Web site: Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7.