FBRS explained

Probable fibrosin-1 long transcript protein is a protein that in humans is encoded by the FBRS gene.^{[1] [2] [3]}

Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998).

Further reading

• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . etal. free .
• Prakash S, Nanji AA, Robbins PW . Fibrosin: A novel lymphokine in alcohol-induced fibrosis . Exp. Mol. Pathol. . 67 . 1 . 40–9 . 1999 . 10493891 . 10.1006/exmp.1999.2274 .
• Prakash S, Robbins PW . Fibrosin: a novel lymphokine in wound healing . Exp. Mol. Pathol. . 71 . 3 . 247–55 . 2002 . 11733950 . 10.1006/exmp.2001.2402 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Prakash S, Paul WE, Robbins PW . Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts . Exp. Mol. Pathol. . 82 . 1 . 42–8 . 2007 . 17083929 . 10.1016/j.yexmp.2006.06.008 .

Notes and References

1. Prakash S, Robbins PW, Wyler DJ . Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin . Proc Natl Acad Sci U S A . 92 . 6 . 2154–8 . Apr 1995 . 7892239 . 42442 . 10.1073/pnas.92.6.2154 . 1995PNAS...92.2154P . free .
2. Prakash S, Robbins PW . Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine . DNA Cell Biol . 17 . 10 . 879–84 . Nov 1998 . 9809749 . 10.1089/dna.1998.17.879 .
3. Web site: Entrez Gene: FBS1 fibrosin 1.