FAT4 explained

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.^{[1] [2]}

FAT4 is associated with the Hippo signaling pathway.^[3]

Clinical significance

Mutations in FAT4 are associated to Hennekam syndrome.^[4]

Further reading

• Katoh Y, Katoh M . Comparative integromics on FAT1, FAT2, FAT3 and FAT4. . Int. J. Mol. Med. . 18 . 3 . 523–8 . 2006 . 16865240 . 10.3892/ijmm.18.3.523. free .
• Caporaso N, Gu F, Chatterjee N. Genome-wide and candidate gene association study of cigarette smoking behaviors. . PLOS ONE . 4 . 2 . e4653 . 2009 . 19247474 . 10.1371/journal.pone.0004653 . Reitsma . Pieter H. . 2644817 . 2009PLoSO...4.4653C . etal. free .
• Liu Y, Blackwood DH, Caesar S . Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder . Molecular Psychiatry . 16. 1. 2–4 . 2010 . 20351715 . 10.1038/mp.2009.107 . etal. 3883627.
• Need AC, Attix DK, McEvoy JM . A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB . Hum. Mol. Genet. . 18 . 23 . 4650–61 . 2009 . 19734545 . 10.1093/hmg/ddp413 . 2773267 . etal.
• Rose JE, Behm FM, Drgon T . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010. 20379614 . 10.2119/molmed.2009.00159 . 2896464. etal.
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Johnson AD, Kavousi M, Smith AV . Genome-wide association meta-analysis for total serum bilirubin levels . Hum. Mol. Genet. . 18 . 14 . 2700–10 . 2009 . 19414484 . 10.1093/hmg/ddp202 . 2701336. etal.
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .

Notes and References

1. Web site: Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila).
2. Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y . Identification of new human cadherin genes using a combination of protein motif search and gene finding methods . J. Mol. Biol. . 337 . 2 . 307–17 . March 2004 . 15003449 . 10.1016/j.jmb.2004.01.026 .
3. Qi C, Zhu YT, Hu L, Zhu YJ . Identification of Fat4 as a candidate tumor suppressor gene in breast cancers . Int. J. Cancer . 124 . 4 . 793–8 . February 2009 . 19048595 . 2667156 . 10.1002/ijc.23775 .
4. 24913602. 2014. Alders. M. Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome. Human Genetics. Al-Gazali. L. Cordeiro. I. Dallapiccola. B. Garavelli. L. Tuysuz. B. Salehi. F. Haagmans. M. A.. Mook. O. R.. Majoie. C. B.. Mannens. M. M.. Hennekam. R. C.. 10.1007/s00439-014-1456-y . 133 . 9. 1161–1167. 14414158.