FARSA (gene) explained

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.^{[1] [2]}

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression

Further reading

• Rodova M, Ankilova V, Safro MG . Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. . Biochem. Biophys. Res. Commun. . 255 . 3 . 765–73 . 1999 . 10049785 . 10.1006/bbrc.1999.0141 .
• Sang Lee J, Gyu Park S, Park H . Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. . Biochem. Biophys. Res. Commun. . 291 . 1 . 158–64 . 2002 . 11829477 . 10.1006/bbrc.2002.6398 . etal.
• Moor N, Linshiz G, Safro M . Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. . Protein Expr. Purif. . 24 . 2 . 260–7 . 2002 . 11858721 . 10.1006/prep.2001.1560 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Grimwood J, Gordon LA, Olsen A . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA . Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent . Proc Natl Acad Sci U S A . 94 . 12 . 6164–9 . Jul 1997 . 9177188 . 21020 . 10.1073/pnas.94.12.6164 . 1997PNAS...94.6164S . free .
2. Web site: Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit.