FARP1 explained

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.^{[1] [2]}

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

See also

• FARP2
• FERM domain
• RhoGEF domain
• Pleckstrin homology domain

Further reading

• Zhuang B, Su YS, Sockanathan S . FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling . Neuron . 61 . 3 . 359–72 . February 2009 . 19217374 . 10.1016/j.neuron.2008.12.022 . 2654783 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Dunham A, Matthews LH, Burton J . The DNA sequence and analysis of human chromosome 13. . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.

Notes and References

1. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y . Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors . Biochem Biophys Res Commun . 241 . 2 . 369–75 . Jan 1998 . 9425278 . 10.1006/bbrc.1997.7826 .
2. Web site: Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived).