FAM3C explained
Protein FAM3C is a protein that in humans is encoded by the FAM3C gene.[1] [2]
Function
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized.[2] FAM3C functions and expression also were studied in mammalian brains[3] [4] which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer's disease (AD), which highlighted FAM3C as a promising therapeutic target for Alzheimer's disease. Moreover, level of FAM3C was claimed to be a biomarker for AD together with saposin D.[5]
Further reading
- Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . November 1998 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM . Lineage-specific gene duplication and loss in human and great ape evolution . PLOS Biology . 2 . 7 . E207 . July 2004 . 15252450 . 449870 . 10.1371/journal.pbio.0020207 . free .
- Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Della Peruta M, Bassi C, Miyazaki K, Sorio C . Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers . FASEB Journal . 19 . 9 . 1125–7 . July 2005 . 15985535 . 10.1096/fj.04-3000fje . free . 33940827 .
- Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A . Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach . Molecular & Cellular Proteomics . 5 . 1 . 157–71 . January 2006 . 16215274 . 10.1074/mcp.M500178-MCP200 . free .
- Guo J, Cheng H, Zhao S, Yu L . GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases . FEBS Letters . 580 . 2 . 581–4 . January 2006 . 16406369 . 10.1016/j.febslet.2005.12.076 . 1013478 .
- Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H . ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells . Cancer Cell . 10 . 3 . 227–39 . September 2006 . 16959614 . 10.1016/j.ccr.2006.07.020 . free .
Notes and References
- Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR . Cloning, expression, and initial characterization of a novel cytokine-like gene family . Genomics . 80 . 2 . 144–50 . August 2002 . 12160727 . 10.1006/geno.2002.6816 .
- Web site: Entrez Gene: FAM3C family with sequence similarity 3, member C.
- Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M . The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor . Nature Communications . 5 . 3917 . June 2014 . 24894631 . 10.1038/ncomms4917 . 2014NatCo...5.3917H . free .
- Liu L, Watanabe N, Akatsu H, Nishimura M . Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease . Neuroscience . 330 . 236–46 . August 2016 . 27256505 . 10.1016/j.neuroscience.2016.05.050 . 24057333 .
- Saposin D and FAM3C are biomarkers for alzheimer's disease. 9 Aug 2011. Davies. Blennow. McGuire. Huw Alun. Kaj. James Norton. US. 7993868.