FAF1 explained

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.^{[1] [2]}

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Further reading

• Chu K, Niu X, Williams LT . A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 25 . 11894–8 . 1996 . 8524870 . 10.1073/pnas.92.25.11894 . 40509 . free .
• Juo P, Kuo CJ, Yuan J, Blenis J . Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. . Curr. Biol. . 8 . 18 . 1001–8 . 1998 . 9740801 . 10.1016/S0960-9822(07)00420-4 . 18129508 . free . 1998CBio....8.1001J .
• Kusk M, Ahmed R, Thomsen B . Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. . Mol. Cell. Biochem. . 191 . 1–2 . 51–8 . 1999 . 10094392 . 10.1023/A:1006840613986 . 257329 . etal.
• Lai CH, Chou CY, Ch'ang LY . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 . etal.
• Buchberger A, Howard MJ, Proctor M, Bycroft M . The UBX domain: a widespread ubiquitin-like module. . J. Mol. Biol. . 307 . 1 . 17–24 . 2001 . 11243799 . 10.1006/jmbi.2000.4462 .
• Jensen HH, Hjerrild M, Guerra B . Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites. . Int. J. Biochem. Cell Biol. . 33 . 6 . 577–89 . 2001 . 11378439 . 10.1016/S1357-2725(01)00039-5 . etal.
• Ryu SW, Kim E . Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. . Biochem. Biophys. Res. Commun. . 286 . 5 . 1027–32 . 2001 . 11527403 . 10.1006/bbrc.2001.5505 .
• Guerra B, Boldyreff B, Issinger OG . FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. . Int. J. Oncol. . 19 . 6 . 1117–26 . 2002 . 11713579 . 10.3892/ijo.19.6.1117.
• De Haro L, Janknecht R . Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. . Nucleic Acids Res. . 30 . 13 . 2972–9 . 2002 . 12087183 . 10.1093/nar/gkf390 . 117045 .
• Imai Y, Nakada A, Hashida R . Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. . Biochem. Biophys. Res. Commun. . 297 . 5 . 1282–90 . 2002 . 12372427 . 10.1016/S0006-291X(02)02380-X . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ryu SW, Lee SJ, Park MY . Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. . J. Biol. Chem. . 278 . 26 . 24003–10 . 2003 . 12702723 . 10.1074/jbc.M302200200 . etal. free .
• Olsen BB, Jessen V, Højrup P . Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus. . FEBS Lett. . 546 . 2–3 . 218–22 . 2003 . 12832043 . 10.1016/S0014-5793(03)00575-1 . 31741359 . etal. free .
• Bjørling-Poulsen M, Seitz G, Guerra B, Issinger OG . The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. . Int. J. Oncol. . 23 . 4 . 1015–23 . 2004 . 12963981 . 10.3892/ijo.23.4.1015.
• Park MY, Jang HD, Lee SY . Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. . J. Biol. Chem. . 279 . 4 . 2544–9 . 2004 . 14600157 . 10.1074/jbc.M304565200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Stoletov KV, Terman BI . Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. . Biochem. Biophys. Res. Commun. . 320 . 1 . 70–5 . 2004 . 15207703 . 10.1016/j.bbrc.2004.05.134 .
• Colland F, Jacq X, Trouplin V . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Ryu SW, Chae SK, Lee KJ, Kim E . Identification and characterization of human Fas associated factor 1, hFAF1 . Biochem Biophys Res Commun . 262 . 2 . 388–94 . Oct 1999 . 10462485 . 10.1006/bbrc.1999.1217 .
2. Web site: Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1.