FAD diphosphatase explained

FAD diphosphatase
Ec Number:	3.6.1.18
Cas Number:	37289-30-8
Go Code:	0047884

In enzymology, a FAD diphosphatase is an enzyme that catalyzes the chemical reaction

FAD + H₂O

\rightleftharpoons AMP + FMN

Thus, the two substrates of this enzyme are FAD and H₂O, whereas its two products are AMP and FMN.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is FAD nucleotidohydrolase. Other names in common use include FAD pyrophosphatase, riboflavin adenine dinucleotide pyrophosphatase, flavin adenine dinucleotide pyrophosphatase, riboflavine adenine dinucleotide pyrophosphatase, and flavine adenine dinucleotide pyrophosphatase. This enzyme participates in riboflavin metabolism.

References

• Ravindranath SD, Rao NA . 1969 . Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus . Arch. Biochem. Biophys. . 133 . 54 - 9 . 5810832 . 10.1016/0003-9861(69)90487-1 . 1 .
• Shin HJ, Mego JL . 1988 . A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization . Arch. Biochem. Biophys. . 267 . 95 - 103 . 2848456 . 10.1016/0003-9861(88)90012-4 . 1 .