| Symbol: | DAO |
| FAD dependent oxidoreductase | |
| Pfam: | PF01266 |
| Pfam Clan: | CL0063 |
| Interpro: | IPR006076 |
| Prosite: | PDOC00753 |
| Scop: | 1kif |
| Membranome Superfamily: | 249 |
In molecular biology, the FAD dependent oxidoreductase family of proteins is a family of FAD dependent oxidoreductases. Members of this family include Glycerol-3-phosphate dehydrogenase, Sarcosine oxidase beta subunit, D-amino-acid dehydrogenase, D-aspartate oxidase .
D-amino acid oxidase (DAMOX or DAO) is an FAD flavoenzyme that catalyses the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterised and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes.
D-aspartate oxidase (DASOX) [1] is an enzyme, structurally related to DAO, which catalyses the same reaction but is active only toward dicarboxylic D-amino acids. In DAO, a conserved histidine has been shown [2] to be important for the enzyme's catalytic activity.