FABP7 explained

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.^[1]

Function

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.^[1]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.^[2] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.^[3]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.^[4]

Role in pathology

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.^[5]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,^[6] with one, that tested for only one SNP, showing negative^[7] and another, with seven SNPs,^[8] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

Further reading

• Börchers T, Hohoff C, Buhlmann C, Spener F . Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation . Prostaglandins, Leukotrienes, and Essential Fatty Acids . 57 . 1 . 77–84 . Jul 1997 . 9250612 . 10.1016/S0952-3278(97)90496-8 .
• Xu LZ, Sánchez R, Sali A, Heintz N . Ligand specificity of brain lipid-binding protein . The Journal of Biological Chemistry . 271 . 40 . 24711–9 . Oct 1996 . 8798739 . 10.1074/jbc.271.40.24711 . free .
• Young JK, Baker JH, Muller T . Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes . Glia . 16 . 3 . 218–26 . Mar 1996 . 8833192 . 10.1002/(SICI)1098-1136(199603)16:3<218::AID-GLIA4>3.0.CO;2-Y . 9757285 .
• Shi YE, Ni J, Xiao G, Liu YE, Fuchs A, Yu G, Su J, Cosgrove JM, Xing L, Zhang M, Li J, Aggarwal BB, Meager A, Gentz R . Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG . Cancer Research . 57 . 15 . 3084–91 . Aug 1997 . 9242429 .
• Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T . Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP) . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1354 . 1 . 24–8 . Oct 1997 . 9375786 . 10.1016/S0167-4781(97)00115-2 .
• Godbout R, Bisgrove DA, Shkolny D, Day RS . Correlation of B-FABP and GFAP expression in malignant glioma . Oncogene . 16 . 15 . 1955–62 . Apr 1998 . 9591779 . 10.1038/sj.onc.1201740 . free .
• Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F . Expression of fatty acid binding proteins is altered in aged mouse brain . Molecular and Cellular Biochemistry . 198 . 1–2 . 69–78 . Aug 1999 . 10497880 . 10.1023/A:1006946027619 . 6180992 .
• Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC . Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein . The Journal of Biological Chemistry . 275 . 35 . 27045–54 . Sep 2000 . 10854433 . 10.1074/jbc.M003001200 . free .
• Rademacher M, Zimmerman AW, Rüterjans H, Veerkamp JH, Lücke C . Solution structure of fatty acid-binding protein from human brain . Molecular and Cellular Biochemistry . 239 . 1–2 . 61–8 . Oct 2002 . 12479569 . 10.1023/A:1020566909213 . 24296178 .
• Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N . Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis . Molecular and Cellular Biology . 23 . 6 . 2213–24 . Mar 2003 . 12612091 . 149461 . 10.1128/MCB.23.6.2213-2224.2003 .
• Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G . Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance . Nucleic Acids Research . 31 . 11 . 2769–77 . Jun 2003 . 12771203 . 156729 . 10.1093/nar/gkg396 .
• Wang M, Liu YE, Goldberg ID, Shi YE . Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG . The Journal of Biological Chemistry . 278 . 47 . 47319–25 . Nov 2003 . 12975368 . 10.1074/jbc.M308131200 . free .
• Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA . Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme . Proceedings of the National Academy of Sciences of the United States of America . 102 . 16 . 5814–9 . Apr 2005 . 15827123 . 556127 . 10.1073/pnas.0402870102 . 2005PNAS..102.5814L . free .
• Liang Y, Bollen AW, Aldape KD, Gupta N . Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma . BMC Cancer . 6 . 97 . 2006 . 16623952 . 1479358 . 10.1186/1471-2407-6-97 . free .
• Kaloshi G, Mokhtari K, Carpentier C, Taillibert S, Lejeune J, Marie Y, Delattre JY, Godbout R, Sanson M . FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status . Journal of Neuro-Oncology . 84 . 3 . 245–8 . Sep 2007 . 17415524 . 10.1007/s11060-007-9377-4 . 23880935 .
• Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S . Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines . BMC Molecular Biology . 12 . 1 . 31 . 2011 . 21771320 . 3162894 . 10.1186/1471-2199-12-31 . free .

External links

• Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers? Schizophrenia Daily News Blog, 2007-11-07
• 10.1371/journal.pbio.0050320 . 5 . A Candidate Gene for a Biological Marker of Schizophrenia in Mice . 2007 . PLOS Biology . e320 . Gross L . 11 . 20076655 . 2071941 . free . - a synopsis for the general audience.

Notes and References

1. Web site: Entrez Gene: FABP7 fatty acid binding protein 7, brain.
2. Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N . Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells . Genes & Development . 19 . 9 . 1028–33 . May 2005 . 15879553 . 1091737 . 10.1101/gad.1302105 .
3. Keilani S, Sugaya K . Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 . BMC Developmental Biology . 8 . 1 . 69 . July 2008 . 18593473 . 2447831 . 10.1186/1471-213X-8-69 . free .
4. Xu LZ, Sánchez R, Sali A, Heintz N . Ligand specificity of brain lipid-binding protein . The Journal of Biological Chemistry . 271 . 40 . 24711–9 . Oct 1996 . 8798739 . 10.1074/jbc.271.40.24711 . free .
5. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T . Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia . American Journal of Human Genetics . 73 . 1 . 34–48 . Jul 2003 . 12802786 . 1180588 . 10.1086/376549 .
6. https://archive.today/20130415183044/http://www.schizophreniaforum.org/res/sczgene/geneoverview.asp?geneID=594 Gene Overview of All Published Schizophrenia-Association Studies for FABP7
7. Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ . An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia . Molecular Psychiatry . 13 . 11 . 1060–8 . Nov 2008 . 17893707 . 10.1038/sj.mp.4002080 . free .
8. Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T . Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype . PLOS Biology . 5 . 11 . e297 . Nov 2007 . 18001149 . 2071943 . 10.1371/journal.pbio.0050297 . free .