F-11,461 Explained

F-11,461 is a drug that acts as an agonist of the 5-HT_1A receptor (K_i = 1.36 nM) that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT₇ (K_i = 9.1 nM) and D₄ (K_i = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.^[1]

See also

• Befiradol
• 8-OH-DPAT

Notes and References

1. Kumar JS, Majo VJ, Hsiung SC, Millak MS, Liu KP, Tamir H, Prabhakaran J, Simpson NR, Van Heertum RL, Mann JJ, Parsey RV . 6 . Synthesis and in vivo validation of [O-methyl-11C]2--4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand . Journal of Medicinal Chemistry . 49 . 1 . 125–134 . January 2006 . 16392798 . 10.1021/jm050725j .