Eyewire Explained

Eyewire
Developer:Sebastian Seung of Princeton University (formerly Massachusetts Institute of Technology)
Director:Amy Sterling
Platforms:Webbrowser (WebGL)
Released:December 10, 2012
Genre:Puzzle, Citizen Science

Eyewire is a citizen science game from Sebastian Seung's Lab at Princeton University. It is a human-based computation game that uses players to map retinal neurons. Eyewire launched on December 10, 2012. The game utilizes data generated by the Max Planck Institute for Medical Research.[1]

Eyewire gameplay is used for neuroscience research by enabling the reconstruction of morphological neuron data, which helps researchers model information-processing circuits.[2] [3]

Gameplay

The player is given a cube with a partially reconstructed neuron branch stretching through it. The player completes the reconstruction by coloring a 2D image with a 3D image generated simultaneously. Reconstructions are compared across players as each cube is submitted, yielding a consensus reconstruction that is later checked by experienced players.

Goal

Eyewire is used to advance the use of artificial intelligence in neuronal reconstruction.[4] The project is also used in research determining how mammals see directional motion.[5] [6]

Methods

The activity of each neuron in a 350 × 300 × 60 μm3 portion of a retina was determined by two-photon microscopy.[7] Using serial block-face scanning electron microscopy, the same volume was stained to bring out the contrast of the plasma membranes, sliced into layers by a microtome, and imaged using an electron microscope.

A neuron is selected by the researchers. The program chooses a cubic volume associated with that neuron for the player, along with an artificial intelligence's best guess for tracing the neuron through the two-dimensional images.[8]

Publications

Accomplishments

Eyewire has been featured by Wired,[18] Nature blog SpotOn,[19] Forbes,[20] Scientific American,[21] and NPR.[22]

Notes and References

  1. Web site: About << Eyewire. April 17, 2014. dead. https://web.archive.org/web/20120213150425/http://eyewire.org/about/. February 13, 2012.
  2. 10.1038/nature13240 . 24805243 . 4074887 . Space–time wiring specificity supports direction selectivity in the retina . Nature . 509 . 7500 . 331–336 . 2014 . Kim . Jinseop S . Greene . Matthew J . Zlateski . Aleksandar . Lee . Kisuk . Richardson . Mark . Turaga . Srinivas C . Purcaro . Michael . Balkam . Matthew . Robinson . Amy . Behabadi . Bardia F . Campos . Michael . Denk . Winfried . Seung . H Sebastian . 2014Natur.509..331. .
  3. Book: 10.1145/2786451.2786455 . '/Command' and Conquer: Analysing Discussion in a Citizen Science Game . Proceedings of the ACM Web Science Conference on ZZZ - Web Sci '15 . 26 . 2015 . Tinati . Ramine . Luczak-Roesch . Markus . Simperl . Elena . Shadbolt . Nigel . Hall . Wendy . 978-1-4503-3672-7 . 2874156 . https://eprints.soton.ac.uk/377766/1/2015___WebScience___EyeWire__Quant_.pdf .
  4. Web site: Neural networks: Theory and Applications. Seunglab.org. 2018-01-29. https://web.archive.org/web/20180130145430/http://seunglab.org/courses/neuralnets15/. 2018-01-30. dead.
  5. Web site: Retina << Eyewire . March 27, 2012 . dead. https://web.archive.org/web/20120324121236/http://eyewire.org/retina/ . March 24, 2012 .
  6. Web site: Eyewire. March 27, 2012.
  7. Web site: Challenge << Eyewire. March 27, 2012. dead. https://web.archive.org/web/20120414005627/http://eyewire.org/challenge/. April 14, 2012.
  8. Web site: Very small sections of neuron. Sebastian Seung. A few more words of explanation for the curious...you color neurons on Eyewire by guiding an artificial intelligence (AI). The AI was trained to color the branches of neurons.. March 18, 2012. March 27, 2012. https://web.archive.org/web/20140419015133/http://forum.eyewire.org/discussion/8/very-small-sections-of-neuron-#Item_11. April 19, 2014. dead.
  9. Web site: At TED, Worldwide Telescope uses Oculus Rift to let attendees experience the universe - Next at Microsoft - Site Home - TechNet Blogs . 2014-04-17 . https://web.archive.org/web/20140418220828/http://blogs.technet.com/b/next/archive/2014/03/19/at-ted-worldwide-telescope-uses-oculus-rift-to-let-attendees-experience-the-universe.aspx#.U1AjneZdXKg . 2014-04-18 . dead.
  10. Web site: Yes, that's Commander Chris Hadfield wearing the Oculus Rift. (And yes, the Internet just exploded.). 26 March 2014. Blog.ted.com. 31 January 2018.
  11. Web site: USA Science & Engineering Festival - The Nation's Largest Science Festival. USASEF. 31 January 2018.
  12. Web site: Science: 2013 International Science and Engineering Visualization Challenge Winners Announced. 5 February 2014. Aaas.org. 31 January 2018.
  13. Web site: Koch2014winners: Cell Press . 2014-04-17 . https://web.archive.org/web/20160506184347/http://www.cell.com/pictureshow/koch2014winners . 2016-05-06 . dead.
  14. Web site: Science For the People, By the People. DiscoverMagazine.com. 31 January 2018.
  15. Web site: Top 13 Citizen Science Projects of 2013 . SciStarter.com. 1 January 2014.
  16. Web site: BIOVISION Catalyzer . 2014-04-17 . dead. https://web.archive.org/web/20140419014924/http://www.biovision.org/focus2-catalyzer.html . 2014-04-19 .
  17. Web site: Top Citizen Science Projects of 2012 - CitizenSci. 31 December 2012. Blogs.plos.org.
  18. Liz . Stinson . 2 August 2013 . A Videogame That Recruits Players to Map the Brain . . 10 November 2019.
  19. Web site: SpotOn Editor . 14 March 2013 . SpotOn NYC: Communication and the brain – A Game to Map the Brain . https://web.archive.org/web/20130318023202/http://www.nature.com/spoton/2013/03/spoton-nyc-communication-and-the-brain-a-game-to-map-the-brain/ . 18 March 2013 . SpotOn (blog) . . 10 November 2019.
  20. Frank . Aaron . with Vivek Wadhwa . 19 August 2013 . 70,000+ Have Played 'Eyewire' Game That Trains Computers to Map the Brain . . 10 November 2019.
  21. Update: EyeWire . . 13 June 2014 . April 17, 2014.
  22. News: Palca . Joe . 5 March 2013 . Wanna Play? Computer Gamers Help Push Frontier of Brain Research . Joe's Big Idea . . NPR . 10 November 2019.

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