Eyes absent homolog 2 explained

Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene.^{[1] [2]}

Function

This gene encodes a member of the eyes absent (EYA) subfamily of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.^[2]

Interactions

EYA2 has been shown to interact with GNAI2^[3] and GNAZ.^[3]

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . Apr 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Zimmerman JE, Bui QT, Steingrímsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, Bonini NM . Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene . Genome Research . 7 . 2 . 128–41 . Feb 1997 . 9049631 . 10.1101/gr.7.2.128 . free .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Melinda Duncan . Duncan MK, Kos L, Jenkins NA, Gilbert DJ, Copeland NG, Tomarev SI . Eyes absent: a gene family found in several metazoan phyla . Mammalian Genome . 8 . 7 . 479–85 . Jul 1997 . 9195991 . 10.1007/s003359900480 . 9660145 .
• Borsani G, DeGrandi A, Ballabio A, Bulfone A, Bernard L, Banfi S, Gattuso C, Mariani M, Dixon M, Donnai D, Metcalfe K, Winter R, Robertson M, Axton R, Brown A, van Heyningen V, Hanson I . EYA4, a novel vertebrate gene related to Drosophila eyes absent . Human Molecular Genetics . 8 . 1 . 11–23 . Jan 1999 . 9887327 . 10.1093/hmg/8.1.11 . free .
• Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR . The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins . The Journal of Biological Chemistry . 275 . 41 . 32129–34 . Oct 2000 . 10906137 . 10.1074/jbc.M004577200 . free .
• Clark SW, Fee BE, Cleveland JL . Misexpression of the eyes absent family triggers the apoptotic program . The Journal of Biological Chemistry . 277 . 5 . 3560–7 . Feb 2002 . 11700312 . 10.1074/jbc.M108410200 . free .
• Fee BE, Doyle CA, Cleveland JL . A novel Eyes Absent 2 protein is expressed in the human eye . Gene . 285 . 1–2 . 221–8 . Feb 2002 . 12039049 . 10.1016/S0378-1119(02)00404-3 .
• Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P . Six and Eya expression during human somitogenesis and MyoD gene family activation . Journal of Muscle Research and Cell Motility . 23 . 3 . 255–64 . 2003 . 12500905 . 10.1023/A:1020990825644 . 42497614 .
• Zhang L, Yang N, Huang J, Buckanovich RJ, Liang S, Barchetti A, Vezzani C, O'Brien-Jenkins A, Wang J, Ward MR, Courreges MC, Fracchioli S, Medina A, Katsaros D, Weber BL, Coukos G . Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth . Cancer Research . 65 . 3 . 925–32 . Feb 2005 . 10.1158/0008-5472.925.65.3 . 15705892 . 25423765 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Eyes absent homolog 2 (EYA2)

Notes and References

1. Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C . A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family . Nature Genetics . 15 . 2 . 157–64 . Feb 1997 . 9020840 . 10.1038/ng0297-157 . 28527865 .
2. Web site: Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila).
3. Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR . The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins . The Journal of Biological Chemistry . 275 . 41 . 32129–34 . Oct 2000 . 10906137 . 10.1074/jbc.M004577200 . free .