Exosome component 8 explained

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.^[1]

Interactions

Exosome component 8 has been shown to interact with:

• Exosome component 5^[2] and
• Exosome component 6.^[2]

Further reading

• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6 . 2066/186665 . free .
• Jiang T, Altman S . A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3′→5′ exoribonuclease activity . Proc. Natl. Acad. Sci. U.S.A. . 99 . 8 . 5295–300 . 2002 . 11929972 . 10.1073/pnas.072083699 . 122763 . free .
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ . Protein-protein interactions of hCsl4p with other human exosome subunits . J. Mol. Biol. . 315 . 4 . 809–18 . 2002 . 11812149 . 10.1006/jmbi.2001.5265 . 2066/261980 . free .
• Chen CY . AU binding proteins recruit the exosome to degrade ARE-containing mRNAs . Cell . 107 . 4 . 451–64 . 2002 . 11719186 . 10.1016/S0092-8674(01)00578-5 . vanc. Gherzi R . Ong SE . 3 . Chan . Edward L. . Raijmakers . Reinout . Pruijn . Ger J.M. . Stoecklin . Georg . Moroni . Christoph . Mann . Matthias . free .
• Jiang T, Altman S . Protein–protein interactions with subunits of human nuclear RNase P . Proc. Natl. Acad. Sci. U.S.A. . 98 . 3 . 920–5 . 2001 . 11158571 . 10.1073/pnas.021561498 . 14685 . free .
• Brouwer R . Three novel components of the human exosome . J. Biol. Chem. . 276 . 9 . 6177–84 . 2001 . 11110791 . 10.1074/jbc.M007603200 . vanc. Allmang C . Raijmakers R . 3 . Van Aarssen . Y . Egberts . WV . Petfalski . E . Van Venrooij . WJ . Tollervey . D . Pruijn . GJ . free . 2066/186951 . free .
• Williams JM, Chen GC, Zhu L, Rest RF . Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth . Mol. Microbiol. . 27 . 1 . 171–86 . 1998 . 9466265 . 10.1046/j.1365-2958.1998.00670.x . free .

Notes and References

1. Web site: Entrez Gene: EXOSC8 exosome component 8.
2. Nov 2002 . Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring . J. Mol. Biol. . 323 . 4 . 653–63 . 12419256 . 10.1016/s0022-2836(02)00947-6. 2066/186665 . free .