Exosome component 1 explained

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.^{[1] [2] [3]}

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.^[4]

Interactions

Exosome component 1 has been shown to interact with:

• Exosome component 5,^[5]
• Exosome component 6,^[5] and
• Exosome component 7.^{[1] [5]}

Further reading

• Lai CH, Chou CY, Ch'ang LY . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 . etal.
• van Hoof A, Staples RR, Baker RE, Parker R . Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. . Mol. Cell. Biol. . 20 . 21 . 8230–43 . 2000 . 11027292 . 86432 . 10.1128/MCB.20.21.8230-8243.2000 .
• Brouwer R, Allmang C, Raijmakers R . Three novel components of the human exosome. . J. Biol. Chem. . 276 . 9 . 6177–84 . 2001 . 11110791 . 10.1074/jbc.M007603200 . etal. free . 2066/186951 . free .
• Brouwer R, Vree Egberts WT, Hengstman GJ . Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. . Arthritis Res. . 4 . 2 . 134–8 . 2002 . 11879549 . 83843 . 10.1186/ar389 . etal . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6 . 2066/186665 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 . etal.

Notes and References

1. Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ . Protein-protein interactions of hCsl4p with other human exosome subunits . J Mol Biol . 315 . 4 . 809–18 . Jan 2002 . 11812149 . 10.1006/jmbi.2001.5265 . 2066/261980 .
2. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M . AU binding proteins recruit the exosome to degrade ARE-containing mRNAs . Cell . 107 . 4 . 451–64 . Nov 2001 . 11719186 . 10.1016/S0092-8674(01)00578-5 . 14817671 . free .
3. Web site: Entrez Gene: EXOSC1 exosome component 1.
4. Web site: Entrez Gene: EXOSC1 exosome component 1.
5. Nov 2002 . Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring . J. Mol. Biol. . 323 . 4 . 653–63 . 12419256 . 10.1016/s0022-2836(02)00947-6. 2066/186665 . free .