Exoribonuclease II explained

Exoribonuclease II
Ec Number:	3.1.13.1
Cas Number:	37288-24-7

Exoribonuclease II (ribonuclease II, ribonuclease Q, BN ribonuclease, Escherichia coli exo-RNase II, RNase II, exoribonuclease (misleading), 5'-exoribonuclease) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

This enzyme has preference for single-stranded RNA.

See also

• 5'-3' exoribonuclease 2

Notes and References

1. Nossal NG, Singer MF . The processive degradation of individual polyribonucleotide chains. I. Escherichia coli ribonuclease II . The Journal of Biological Chemistry . 243 . 5 . 913–22 . March 1968 . 4867942 .
2. Schmidt FJ, McClain WH . An Escherichia coli ribonuclease which removes an extra nucleotide from a biosynthetic intermediate of bacteriophage T4 proline transfer RNA . Nucleic Acids Research . 5 . 11 . 4129–39 . November 1978 . 364422 . 342738 . 10.1093/nar/5.11.4129 .
3. Shimura Y, Sakano H, Nagawa F . Specific ribonucleases involved in processing of tRNA precursors of Escherichia coli. Partial purification and some properties . European Journal of Biochemistry . 86 . 1 . 267–81 . May 1978 . 350582 . 10.1111/j.1432-1033.1978.tb12308.x . free .
4. Sporn MB, Lazarus HM, Smith JM, Henderson WR . Studies on nuclear exoribonucleases. 3. Isolation and properties of the enzyme from normal and malignant tissues of the mouse . Biochemistry . 8 . 4 . 1698–706 . April 1969 . 5805304 . 10.1021/bi00832a053 .