Examples of in vivo transdifferentiation by lineage-instructive approach explained

A list of examples of in vivo transdifferentiation through transfection:^[1]

• mouse hepatocytes → B cells (Pdx1)^[2]
• exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)^[3]
• nonsensory cells → inner hair cells (Atoh1 and MathI)^[4]
• non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)^[5]

Through excision:

• B-cell precursors → hematopoietic progenitors(-Pax5)^[6]
• In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)^[7]

See also

• Transdifferentiation
• Induced stem cells

References

1. Pournasr . B. . Khaloughi . K. . Salekdeh . G. H. . Totonchi . M. . Shahbazi . E. . Baharvand . H. . 10.1002/stem.760 . Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells . Stem Cells . 29 . 12 . 1933–1941 . 2011 . 21997905 . free .
2. Ferber . S. . Halkin . A. . Cohen . H. . Ber . I. . Einav . Y. . Goldberg . I. . Barshack . I. . Seijffers . R. . Kopolovic . J. . Kaiser . N. . Karasik . A. . Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia . Nature Medicine . 6 . 5 . 568–572 . 10.1038/75050 . 2000 . 10802714 . 19015530 .
3. Zhou . Q. . Brown . J. . Kanarek . A. . Rajagopal . J. . Melton . D. A. . In vivo reprogramming of adult pancreatic exocrine cells to β-cells . 10.1038/nature07314 . Nature . 455 . 7213 . 627–632 . 2008 . 18754011 . 9011918 . 2008Natur.455..627Z . 205214877 .
4. Izumikawa . M. . Minoda . R. . Kawamoto . K. . Abrashkin . K. A. . Swiderski . D. L. . Dolan . D. F. . Brough . D. E. . Raphael . Y. . 10.1038/nm1193 . Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals . Nature Medicine . 11 . 3 . 271–276 . 2005 . 15711559 . 18319476 .
5. Takeuchi . J. K. . Bruneau . B. G. . 10.1038/nature08039 . Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors . Nature . 459 . 7247 . 708–711 . 2009 . 19396158 . 2728356 . 2009Natur.459..708T .
6. Cobaleda . C. S. . Jochum . W. . Busslinger . M. . 10.1038/nature06159 . Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors . Nature . 449 . 7161 . 473–477 . 2007 . 17851532 . 2007Natur.449..473C . 4414856 .
7. Uhlenhaut . N. H. . Jakob . S. . Anlag . K. . Eisenberger . T. . Sekido . R. . Kress . J. . Treier . A. C. . Klugmann . C. . Klasen . C. . 10.1016/j.cell.2009.11.021 . Holter . N. I. . Riethmacher . D. . Schütz . G. N. . Cooney . A. J. . Lovell-Badge . R. . Treier . M. . Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation . Cell . 139 . 6 . 1130–1142 . 2009 . 20005806 . free .