Examples of in vitro transdifferentiation by initial epigenetic activation phase approach explained
List:[1]
- Human dermal fibroblasts → multilineage blood progenitors (Oct4 and cytokine treatment)[2]
- Mouse dermal fibroblasts → polygonal hyaline chondrogenic cells (Klf4, c-Myc, Sox9)[3]
- Mouse dermal fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4)[4]
- Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4)[5]
See also
References
- Pournasr . B. . Khaloughi . K. . Salekdeh . G. H. . Totonchi . M. . Shahbazi . E. . Baharvand . H. . 10.1002/stem.760 . Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells . Stem Cells . 29 . 12 . 1933–1941 . 2011 . 21997905 . free .
- Szabo . E. . Rampalli . S. . Risueño . R. M. . Schnerch . A. . Mitchell . R. . Fiebig-Comyn . A. . Levadoux-Martin . M. . Bhatia . M. . 10.1038/nature09591 . Direct conversion of human fibroblasts to multilineage blood progenitors . Nature . 468 . 7323 . 521–526 . 2010 . 21057492 . 2010Natur.468..521S . 205223078 .
- Hiramatsu . K. . Sasagawa . S. . Outani . H. . Nakagawa . K. . Yoshikawa . H. . Tsumaki . N. . 10.1172/JCI44605 . Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors . Journal of Clinical Investigation . 121 . 2 . 640–657 . 2011 . 21293062 . 3026734 .
- Efe . J. A. . Hilcove . S. . Kim . J. . Zhou . H. . Ouyang . K. . Wang . G. . Chen . J. . Ding . S. . 10.1038/ncb2164 . Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy . Nature Cell Biology . 13 . 3 . 215–222 . 2011 . 21278734 . 5310172 .
- Kim . J. . Efe . J. A. . Zhu . S. . Talantova . M. . Yuan . X. . Wang . S. . Lipton . S. A. . Zhang . K. . Ding . S. . 10.1073/pnas.1103113108 . Direct reprogramming of mouse fibroblasts to neural progenitors . Proceedings of the National Academy of Sciences . 108 . 19 . 7838–7843 . 2011 . 21521790 . 3093517 . free . 2011PNAS..108.7838K .
