Atazanavir/cobicistat explained

Type:combo
Component1:Atazanavir
Class1:HIV protease inhibitor
Component2:Cobicistat
Class2:Cytochrome P450 (CYP3A) inhibitor
Tradename:Evotaz
Dailymedid:Atazanavir_and_cobicistat
Atc Prefix:J05
Atc Suffix:AR15
Legal Uk:POM
Legal Uk Comment:[1]
Legal Us:Rx-only
Legal Us Comment:[2]
Legal Eu:Rx-only
Legal Eu Comment:[3]
Cas Number:2446322-19-4
Kegg:D10753

Atazanavir/cobicistat, sold under the brand name Evotaz, is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS. It contains atazanavir and cobicistat.[4] Atazanavir is an HIV protease inhibitor and cobicistat is an inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family.

Atazanavir/cobicistat was approved by the Food and Drug Administration (FDA) for medical use in United States in January 2015.[5] [6] It was approved for medical use in the European Union in July 2015.

Medical uses

Atazanavir/cobicistat is indicated for use in combination with other antiretroviral agents for the treatment of HIV‑1 infection in people weighing at least 35kg (77lb).

External links

Notes and References

  1. Web site: Evotaz 300 mg/150 mg film-coated tablets - Summary of Product Characteristics (SmPC) . (emc) . 9 July 2021.
  2. Web site: Evotaz- atazanavir and cobicistat tablet . DailyMed . 25 May 2021.
  3. Web site: Evotaz EPAR . European Medicines Agency (EMA) . 17 September 2018 . 25 May 2021.
  4. Crutchley RD, Guduru RC, Cheng AM . Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection . HIV/AIDS: Research and Palliative Care. 8 . 47–65 . 2016 . 27022304 . 4790521 . 10.2147/HIV.S99063 . free .
  5. U.S. Food and Drug Administration Approves Bristol-Myers Squibb's Evotaz (atazanavir and cobicistat) for the Treatment of HIV-1 Infection in Adults . Bristol-Myers Squibb . 2018-06-28 . 2020-08-08 . https://web.archive.org/web/20200808213616/https://news.bms.com/press-release/financial-news/us-food-and-drug-administration-approves-bristol-myers-squibbs-evotaz-a . dead .
  6. Web site: Evotaz (atazanavir and cobicistat) Tablet . U.S. Food and Drug Administration (FDA) . 15 April 2016 . 25 May 2021 . Web site: Summary Report.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Atazanavir/cobicistat".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.