Evogliptin Explained

Iupac Name:(3R)-4-[(3''R'')-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3--2-piperazinone
Tradename:Suganon
Routes Of Administration:By mouth
Cas Number:1222102-29-5
Atc Prefix:A10
Atc Suffix:BH07
Pubchem:25022354
Chemspiderid:26339341
Unii:09118300L7
Chembl:1779710
Kegg:D11023
Synonyms:DA-1229
C:19
H:26
F:3
N:3
O:3
Smiles:CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@@H](Cc2cc(c(cc2F)F)F)N
Stdinchi:1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1
Stdinchikey:LCDDAGSJHKEABN-MLGOLLRUSA-N

Evogliptin (INN; trade names Suganon, Evodine) is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor or "gliptin" class of drugs.[1] It was developed by the South Korean pharmaceutical company Dong-A ST and is approved for use in South Korea[2] and Russia.[3] In a meta-analysis involving data from 6 randomized controlled trials (887 patients), Dutta et. al. demonstrated the good glycaemic efficacy and safety of this medicine as compared to other DPP4 inhibitors like sitagliptin and linagliptin. [4]

Notes and References

  1. McCormack PL . Evogliptin: First Global Approval . Drugs . 75 . 17 . 2045–9 . November 2015 . 26541763 . 10.1007/s40265-015-0496-5 . 46450821 .
  2. News: Dong-A ST's DPP4 inhibitor, SUGANON, got approved for type 2 diabetes in Korea . October 2, 2015 . pipelinereview.com . February 1, 2017 . June 30, 2022 . https://web.archive.org/web/20220630134355/https://pipelinereview.com/index.php/2015100259148/Small-Molecules/Dong-A-STs-DPP4-inhibitor-SUGANON-got-approved-for-type-2-diabetes-in-Korea.html . dead .
  3. Web site: Evodine (evogliptin) film-coated tablets. Full prescribing information . Russian State Register of Medicines . Russian.
  4. Dutta D, Bhattacharya S, Krishnamurthy A, Sharma LK, Sharma M . Efficacy and Safety of Novel Dipeptidyl-Peptidase-4 Inhibitor Evogliptin in the Management of Type 2 Diabetes Mellitus: A Meta-Analysis. . Indian J Endocrinol Metab . 24 . 5 . Nov 2020 . 434–445 . 33489850 . 10.4103/ijem.IJEM_418_20 . 7810058 . free .