Eva Nogales Explained

Eva Nogales
Birth Place:Colmenar Viejo, Madrid, Spain
Alma Mater:B.S., physics, Autonomous University of Madrid in 1988, PhD, University of Keele, 1992
Thesis Url:https://www.worldcat.org/oclc/
Workplaces:University of California, Berkeley, Howard Hughes Medical Institute, Synchrotron Radiation Source
Occupation:Biophysicist, professor
Known For:The first to determine the atomic structure of tubulin by electron crystallography
Spouse:Howard Padmore
Children:2
Awards:Early Career Award, American Society for Cell Biology (2005)
Chabot Science Award for Excellence (2006)
Shaw Prize (2023)

Eva Nogales (born in Colmenar Viejo, Madrid, Spain) is a Spanish-American biophysicist at the Lawrence Berkeley National Laboratory and a professor at the University of California, Berkeley, where she served as head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015–2020). She is a Howard Hughes Medical Institute investigator.

Nogales is a pioneer in using electron microscopy for the structural and functional characterization of macromolecular complexes. She used electron crystallography to obtain the first structure of tubulin and identify the binding site of the important anti-cancer drug taxol. She is a leader in combining cryo-EM, computational image analysis and biochemical assays to gain insights into function and regulation of biological complexes and molecular machines.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2]

Early life and education

Eva Nogales obtained her BS degree in physics from the Autonomous University of Madrid in 1988.[3] She later earned her PhD from the University of Keele in 1992 while working at the Synchrotron Radiation Source under the supervision of Joan Bordas.

Career

During her post-doctoral work in the laboratory of Ken Downing at the Lawrence Berkeley National Laboratory, Eva Nogales was the first to determine the atomic structure of tubulin and the location of the taxol-binding site by electron crystallography.[4] [5] [6] She became an assistant professor in the Department of Molecular and Cell Biology at the University of California, Berkeley in 1998. In 2000 she became an investigator in the Howard Hughes Medical Institute. As cryo-EM techniques became more powerful,[7] she became a leader in applying cryo-EM to the study of microtubule structure and function[8] and other large macromolecular assemblies such as eukaryotic transcription and translation initiation complexes,[9] [10] the polycomb complex PRC2, and telomerase.[11]

Selected publications

Awards

Personal life

Nogales is married to Howard Padmore and they have two children.[20]

References

  1. News: How to See Living Machines. 2016-12-07. Medical Design Technology. 2018-02-03.
  2. Web site: Eva Nogales. HHMI.org. en. 2019-03-23.
  3. Web site: Nogales Lab – CryoEM – Publications . 2022-03-16 . cryoem.berkeley.edu . 2021-12-25 . https://web.archive.org/web/20211225201816/http://cryoem.berkeley.edu/eva.html . dead .
  4. Nogales. E.. Wolf. S. G.. Khan. I. A.. Ludueña. R. F.. Downing. K. H.. 1995-06-01. Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature. 375. 6530. 424–427. 10.1038/375424a0. 0028-0836. 7760939. 1995Natur.375..424N. 4338992.
  5. Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature, 391, 199-203.
  6. Nogales. E.. Whittaker. M.. Milligan. R. A.. Downing. K. H.. 1999-01-08. High-resolution model of the microtubule. Cell. 96. 1. 79–88. 0092-8674. 9989499. 10.1016/s0092-8674(00)80961-7. 18422680. free.
  7. Callaway. Ewen. 2015-09-10. The revolution will not be crystallized: a new method sweeps through structural biology. Nature. 525. 7568. 172–174. 10.1038/525172a. 1476-4687. 26354465. 2015Natur.525..172C. free.
  8. Book: Downing. Kenneth H.. Nogales. Eva. Cryoelectron Microscopy Applications in the Study of Tubulin Structure, Microtubule Architecture, Dynamics and Assemblies, and Interaction of Microtubules with Motors . 2010. Cryo-EM, Part C: Analyses, Interpretation, and Case studies. Methods in Enzymology. 483. 121–142. 10.1016/S0076-6879(10)83006-X. 1557-7988. 4165512. 20888472. 9780123849939.
  9. Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell, 152(1):120–131.
  10. Web site: Stop-Motion View of DNA-Binding Complex May Animate Drug Discovery. 2018-11-20. GEN – Genetic Engineering and Biotechnology News. en-US. 2019-03-23.
  11. Web site: The 3D Structure of Telomerase: Uncovering Its Role in Human Disease. Drug Discovery from Technology Networks. en. 2019-03-23.
  12. Web site: Early Career Life Scientist Award. ASCB. en-US. 2019-03-23.
  13. Web site: Announcing the winners of the 2015 Protein Society Awards. EurekAlert!. en. 2019-03-23.
  14. Web site: Eva Nogales . nasonline.org . 16 April 2021 . 29 December 2023.
  15. News: 9 campus faculty selected for membership in American Academy of Arts and Sciences The Daily Californian. 2016-04-22. The Daily Californian. 2018-02-03. en-US.
  16. Web site: Women in Cell Biology Awards. ASCB. en-US. 2019-03-23.
  17. Web site: Nogales Receives 2019 Grimwade Medal. 2019-03-07. Biosciences Area. en-US. 2019-03-23.
  18. Web site: AAAS Honors Outstanding Scientific Contributors as 2021 AAAS Fellows American Association for the Advancement of Science . 2022-03-16 . www.aaas.org . en.
  19. https://www.shawprize.org/news/announcement-press-conference-2023-press-release Shaw Prize 2023
  20. Web site: Phelan . Laura . Eva Nogales . . 1 December 2014 . 29 December 2023.

External links

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