Eva Neer Explained

Eva Neer
Nationality:American of Polish origin
Birth Name:Eva Augenblick
Birth Date:1937
Birth Place:Warsaw, Poland
Death Date:2000, age 62
Death Place:Cambridge, Massachusetts
Spouse:Robert M. Neer
Education:Radcliffe College, Columbia University
Awards:National Academy of Sciences
Child:Two sons, Robert and Richard
Fields:Biochemist and cell-biologist
Known For:G-protein subunit structure and function
Workplaces:Harvard University

Eva Julia Neer (1937–2000) was an American physician (Columbia University P&S), biochemist, and cell-biology scientist who gained U.S. national research awards (FASEB, 1987; American Heart Association, 1996) for her discoveries on G-protein subunit structure and function. She described the physiological roles of these subunits as an integrated and versatile molecular system of signal transduction for membrane-receptor regulation of cell function. Her research concepts turned her into a world leader in G-protein studies and impinged widely on the general understanding of cell behavior.[1] [2] [3]

Biography

Born Eva Augenblick in Warsaw, came to New York at age eight with her parents and grew up in Queens and Scarsdale.[4] Neer's family fled Warsaw at war's onset in 1939, emigrated first to Brazil, and soon after to the U.S.. In Warsaw, her father had practiced private corporate law, which he was unable to pursue in the US, but her parents inspired in Neer her love for scholarly endeavors.[2] She graduated with honors from Bronxville High School in 1955, being awarded a Regent’s college scholarship by the State Education Department.[5] Eva Augenblick attended Radcliffe College and graduated from Barnard College in 1959. A list of student acquaintances of hers at high school and college would include notable achievers such as economist Fischer Black, psychologist Robert L. Helmreich,[6] and endocrinologist Robert M. Neer[7] whom she married.[8] Neer graduated as a physician at Columbia University in 1963. Three years later, she joined Harvard University where she worked continuously for more than three decades. Neer has been singled out for her "efforts to help women advance up the academic ladder".[9] She died of complications from breast cancer in 2000, survived by her husband and two sons, Robert and Richard.[10] A personal account of Neer´s professional life was given by her close colleague David E. Clapham in an obituary note.[11]

Academic career

Neer joined Harvard research staff in 1966. She was appointed Assistant Professor of Medicine in 1976, and full professor in 1991. She was ascribed to the Cardiology Division at Brigham and Women's Hospital. Neer served on the Board of Tutors in Biochemical Sciences at Harvard College, as well as on the Harvard Students Research Committee at the Harvard Medical School. She combined the tools of chemistry, biology, physics and molecular biology to explain how cells interpret the messages they get from light, hormones and neurotransmitters. The author of numerous papers, she was elected to both the U.S. National Academy of Sciences and the Institute of Medicine of the National Academy of Sciences and earned membership in the American Academy of Arts and Sciences and the Polish Institute of Arts and Sciences of America. She was honored with the FASEB prize for basic research in 1987 and the American Heart Association’s basic research prize in 1996. She was also an adviser to the National Institutes of Health.[1] [2] [3]

Research

Neer's early research, performed under the guidance of Guido Guidotti,[12] was devoted to study aspects of hemoglobin chemistry. These included the role of sulfhydryl groups of α and β chains on the quaternary conformation of the molecule. She showed their importance in subunit interface interaction and functional cooperativity for oxygen binding. This binding is an essential property for oxygen transport in blood and is often referred as Bohr effect.[13]

While still at Guidotti's lab, Neer undertook independent research on the biochemical mechanisms of vasopressin's action on kidney's distal tubules. She described the purification and kinetic properties of vasopressin-sensitive adenylate cyclase from rat renal medulla.[14] It would be later shown that vasopressin[15] acts through a G protein-coupled receptor. This was the topic of Neer's work for most of her research career.

In order to dissect out different aspects of G protein messaging complexities Neer studied a variety of tissues including brain cortex, rat testis, pigeon erythrocytes, heart, brain, retina-rods. Some of her most cited research findings include:

During the course of her career Neer authored a number of highly cited review articles on structural and functional aspects of G protein and its subunits.[27] [28] [29] [30] [31]

Awards and honors

External links

Notes and References

  1. Web site: Professor of Medicine Eva J. Neer Dies at 62. Harvard Gazette. 2 March 2000. Sep 27, 2017.
  2. Web site: Remembering Dr. Eva Neer, read at the Faculty of Medicine meeting on Dec. 18, 2002 . Harvard Gazette . March 6, 2003 . Jan 2, 2014 . dead . https://web.archive.org/web/20140102192617/http://www.news.harvard.edu/gazette/2003/03.06/18-mm.html . January 2, 2014 .
  3. Web site: Dr. Eva J. Neer, in memorial . BioMolecular Engineering Research Center . 2000-02-21 . Jan 2, 2014 . https://web.archive.org/web/20140102192636/http://haldane.bu.edu/memoriam/neer.html . January 2, 2014 . dead .
  4. News: Saxon, Wolfgang . Eva Julia Neer, 62, Biochemist Known for Work With Proteins . The New York Times . 2000-02-26 . Jan 2, 2014.
  5. Web site: HS,Yonkers,N.Y,May 13, 1955 . Archives of the Yonkers NY Herald Statesman . Fultonhistory.com . Jan 2, 2014.
  6. http://psycnet.apa.org/journals/amp/68/6/470/
  7. Web site: Dr. Robert M. Neer, MD - Boston, MA - Internal Medicine | Healthgrades.com . 2 January 2014 . 2 January 2014 . https://web.archive.org/web/20140102200118/http://www.healthgrades.com/physician/dr-robert-neer-25g89 . dead .
  8. Web site: Perry . Mehrling . Fischer Black and the Revolutionary Idea of Finance . Dmmserver.com . Jan 2, 2014 . 4 March 2016 . https://web.archive.org/web/20160304001918/http://www.dmmserver.com/DialABook/978/047/145/9780471457329.html . dead .
  9. Web site: Professor of Medicine Eva J. Neer Dies at 62 . 1 January 2014 . 2 January 2014 . https://web.archive.org/web/20140102192532/http://news.harvard.edu/gazette/2000/03.02/neer.html . dead .
  10. Web site: Eva Julia Neer, 62, Biochemist, Heart Researcher . Chicago Tribune . 2000-02-28 . Jan 2, 2014.
  11. Clapham. David E.. Remembering Eva Neer. Cell. 2000. 101. 3. 247–248. 10.1016/S0092-8674(02)71135-5. free.
  12. Web site: Guido Guidotti . Molecular & Cellular Biology - Harvard University . Jan 2, 2014 . 15 November 2016 . https://web.archive.org/web/20161115183604/https://www.mcb.harvard.edu/mcb/faculty/profile/guido-guidotti/ . dead .
  13. Neer. EJ. Guidotti, G. The recombination of α and β chains of human hemoglobin. Effect of sulfhydryl group modifications.. J. Biol. Chem.. 1970. 245. 3. 570–3. 10.1016/S0021-9258(18)63370-8. 5412713. free.
  14. Neer. EJ. The vasopressin-sensitive adenylate cyclase of the rat renal medulla.. J. Biol. Chem.. 1973. 248. 13. 4775–81. 10.1016/S0021-9258(19)43732-0. 4352409. free.
  15. Prat. AG. Ausiello, DA . Cantiello, HF . Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels.. American Journal of Physiology. Cell Physiology. 1993. 265. 1 Pt 1. C218–23. 8393279. 10.1152/ajpcell.1993.265.1.C218.
  16. Neer. EJ. Physical and functional properties of adenylate cyclase from mature rat testis. J. Biol. Chem.. 1978. 253. 16. 5808–12. 10.1016/S0021-9258(17)30340-X. 670231. free.
  17. Neer. EJ. Size and detergent binding of adenylate cyclase from bovine cerebral cortex. J. Biol. Chem.. 1978. 253. 5. 1498–502. 10.1016/S0021-9258(17)34894-9. 627551. free.
  18. Marshak. DR. Neer, EJ. The site of α-chymotryptic activation of pigeon erythrocyte adenylate cyclase. J. Biol. Chem.. 1980. 255. 10. 4781–5. 10.1016/S0021-9258(19)85565-5. 7372611. free.
  19. Salter. RS. Krinks, MH . Klee, CB . Neer, EJ . Calmodulin activates the isolated catalytic unit of brain adenylate cyclase. J. Biol. Chem.. 1981. 256. 19. 9830–3. 10.1016/S0021-9258(19)68703-X. 6268633. free.
  20. Winslow. JW. Bradley, JD . Smith, JA . Neer, EJ . Reactive sulfhydryl groups of α39, a guanine nucleotide-binding protein from brain. Location and function. J. Biol. Chem.. 1987. 262. 10. 4501–7. 10.1016/S0021-9258(18)61220-7. 3104318. free.
  21. Logothetis. DE. Kurachi, Y . Galper, J . Neer, EJ . Clapham, DE . The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 1987. 325. 6102. 321–6. 10.1038/325321a0. 2433589. 1987Natur.325..321L . 4338529.
  22. Logothetis. DE. Kim, DH . Northup, JK . Neer, EJ . Clapham, DE . Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc. Natl. Acad. Sci. USA. 1988. 85. 16. 5814–8. 10.1073/pnas.85.16.5814. 2457901. 281855. 1988PNAS...85.5814L . free.
  23. Kim. SY. Ang, SL . Bloch, DB . Bloch, KD . Kawahara, Y . Tolman, C . Lee, R . Seidman, JG . Neer, EJ . Identification of cDNA encoding an additional α subunit of a human GTP-binding protein: expression of three αi subtypes in human tissues and cell lines. Proc. Natl. Acad. Sci. USA. 1988. 85. 12. 4153–4257. 10.1073/pnas.85.12.4153. 3132707. 280384. 1988PNAS...85.4153K . free.
  24. Li. Y. Mende, U . Lewis, C . Neer, EJ . Maintenance of cellular levels of G-proteins: different efficiencies of αs and αo synthesis in GH3 cells. Biochem. J.. 1996. 318. 1071–7. 8836158. 1217725. Pt 3. 10.1042/bj3181071.
  25. Panchenko. MP. Saxena, K . Li, Y . Charnecki, S . Sternweis, PM . Smith, TF . Gilman, AG . Kozasa, T . Neer, EJ . Sites important for PLCβ2 activation by the G Protein βγ subunit map to the sides of the β propeller structure. J. Biol. Chem.. Oct 23, 1998. 273. 43. 28298–304. 10.1074/jbc.273.43.28298. 9774453. free.
  26. Li. Y. Sternweis, PM . Charnecki, S . Smith, TF . Gilman, AG . Neer, EJ . Kozasa, T . Sites for Gα binding on the G protein β subunit overlap with sites for regulation of phospholipase Cβ and adenylyl cyclase. J. Biol. Chem.. 1998. 273. 26. 16265–72. 10.1074/jbc.273.26.16265. 9632686. free.
  27. Neer. EJ. Structural and functional studies of the Go protein. Soc. Gen. Physiol. Series. 1990. 45. 143–51. 2116036.
  28. Clapham. DE. Neer, EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 1993. 365. 6445. 403–6. 10.1038/365403a0. 8413584. 1993Natur.365..403C . 4245662.
  29. Neer. EJ. Heterotrimeric G proteins: organizers of transmembrane signals. Cell. 1995. 80. 2. 249–57. 10.1016/0092-8674(95)90407-7. 7834744. 10095565. free.
  30. Neer. EJ. Clapham, DE. Roles of G protein subunits in transmembrane signalling. Nature . 1988. 333. 6169. 129–34. 10.1038/333129a0. 3130578. 1988Natur.333..129N . 4256130.
  31. G protein βγ subunits . 1997 . 10.1146/annurev.pharmtox.37.1.167 . 9131251 . 1 January 2014 . 13 July 2020 . https://web.archive.org/web/20200713171052/https://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.37.1.167?journalCode=pharmtox . dead . Clapham . D. E. . Neer . E. J. . Annu. Rev. Pharmacol. Toxicol. . 37 . 167–203 .
  32. Web site: Damon Runyon Fellows + Grantees (by award year): '70s . Damon Runyon Cancer Research Foundation . Jan 2, 2014 . https://web.archive.org/web/20140102192651/http://www.damonrunyon.org/for_scientists/more/damon_runyon_fellows_by_award_year_70s . January 2, 2014 . dead .
  33. Web site: The M.D.-Ph.D. Program at Harvard Medical School . 23 January 2014 . 2 February 2014 . https://web.archive.org/web/20140202175126/http://www.hms.harvard.edu/md_phd/events/speakers.html . dead .

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