| Country: | EUR |
| Type: | E |
| Route: | 81 |
| Length Km: | 956 |
| Map Custom: | yes |
| Direction A: | South-East |
| Terminus A: | Constanța, Romania |
| Direction B: | North-West |
| Terminus B: | Mukachevo, Ukraine |
| Countries: |  Romania Ukraine |
European route E 81 is a road part of the International E-road network. It begins in Constanța, Romania and ends in Mukachevo, Ukraine. The road is 956km (594miles) long.
The road follows the route: Mukachevo – Halmeu – Satu Mare – Zalău – Cluj-Napoca – Turda – Sebeș – Sibiu – Pitești – București – Lehliu – Fetești – Cernavodă – Constanța.[1]
Mukachevo (Start of concurrency with) – Berehove
Livada (End of concurrency with) – Satu Mare
Supuru de Sus – Zalău – Cluj-Napoca
Cluj-Napoca (Start of concurrency with) – Turda (End of concurrency with) – Alba Iulia – Sebeș (Start of concurrency with) – Sibiu (End of concurrency with)
Sibiu
Sibiu (Start of concurrency with) – Veștem (End of concurrency with)
Veștem – Râmnicu Vâlcea – Pitești
Bucharest – Fetești – Cernavodă – Constanța
Constanța – Agigea – Port of Constanța