| Country: | EUR |
| Type: | E |
| Route: | 578 |
| Length Km: | 288 |
| Map: | E 578.png |
| Map Notes: | E-roads in Romania, with E578 in red |
| Terminus A: | Sărăţel |
| Terminus B: | Chichiș |
| Countries: |  Romania |
European route E 578 is a European B class road in Romania, connecting the cities Sărăţel and Chichiș.