| Country: | EUR |
| Type: | E |
| Route: | 53 |
| Length Km: | 285 |
| Map Custom: | yes |
| Direction A: | North |
| Terminus A: | Plzeň, Czech Republic |
| Direction B: | South |
| Terminus B: | Munich, Germany |
| Countries: |  Czech Republic Germany |
European route E53 forms part of the International E-road network. It runs from Plzeň in the Czech Republic, to Munich, Germany.
Its route is: Plzeň – Deggendorf – Landshut – Munich.