| Country: | UKR |
| Type: | E |
| Route: | 40 |
| Maint: | Ukravtodor |
| Direction A: | West |
| Terminus A: | at Poland border |
| Junction: |
|
| Direction B: | East |
| Terminus B: | at Russia border |
European route E 40 (E 40) is a west–east European route, running from the port of Calais in France to Altai Mountains near Ridder in Kazakhstan.
In Ukraine, the highway runs through northern regions from the Polish border near Krakovets through Lviv, Zhytomyr, Kyiv, Poltava, Kharkiv, and Luhansk to the Russian border near Izvaryne.
Route follows,,, and . It passes nine regions: Lviv Oblast, Rivne Oblast, Zhytomyr Oblast, Kyiv Oblast, Kyiv City, Poltava Oblast, Kharkiv Oblast, Donetsk Oblast, and Luhansk Oblast.
| Route E40 | |||
| Lviv Oblast | |||
| Yavoriv Raion | |||
| Krakovets |  Poland border | ||
| near Yavoriv | |||
| Novoiavorivsk | |||
| Lviv Raion | |||
| Ryasne-Ruske | towards Lviv city • Lviv ring road | ||
| Kholodnovidka | • Horodotska vulytsia | access to Lviv city | |
| • Stryiska vulytsia | near Solonka • end point of | ||
| near Pasiky-Zubrytski | |||
| near Vynnyky | |||
| near Hamaliivka • (M06 city route) • Lviv ring road | |||
| Mali Pidlisky | |||
| Zolochiv Raion | |||
| Busk | loops north of the city | ||
| Olesko | loops north of the city | ||
| near Brody | |||
| Rivne Oblast | |||
| Radyvyliv Raion | |||
| Radyvyliv | loops north of the city | ||
| Dubno Raion | |||
| near Dubno | |||
| Rivne Raion | |||
| Velyka Omelyana | Dubenska vulytsia | Rivne south loop | |
| • vulytsia Vyacheslava Chornovola | near Kvasyliv | ||
| • Kyivska vulytsia | near Kruhle • Rivne south loop | ||
| Hoshcha Raion | |||
| near Hoshcha | |||
| Korets Raion | |||
| Korets | loops south of the city | ||
| Zhytomyr Oblast | |||
| Zviahel Raion | |||
| Zviahel | loops north of the city | ||
| Pulyny Raion | |||
| Zhytomyr Raion | |||
| M06 city route | Zhytomyr north loop • near Ivanivka | ||
| near Oliivka | |||
| M06 city route | Zhytomyr north loop • near Hlybochytsia | ||
| Korostyshiv Raion | |||
| Korostyshiv | loops north of the city | ||
| Radomyshl Raion | |||
| Brusyliv Raion | |||
| Kyiv Oblast | |||
| Bucha Raion | |||
| Kyiv | |||
| Kyiv ring road • prospekt Peremohy | near Sviatoshyn (Kyiv) • end of | ||
| Kyiv Ring Road | |||
| Borshchahivka | near Sofiivska Borshchahivka | ||
| Teremky | • Kyiv ring road • streets of Kyiv | ||
| prospekt Akademika Hlushakoho | |||
| Demiivka | streets of Kyiv | ||
| Saperno-Slobidska vulytsia | |||
| prospect Mykoly Bazhana | |||
| Kharkivska ploshcha | • streets of Kyiv | near the Park of Partisans Glory | |
| Kyiv Oblast | |||
| Boryspil Raion | |||
| Shchaslyve | near Prolisky | ||
| Boryspil International Airport | access route | ||
| Boryspil | |||
| near Ivankiv | |||
| Brovary Raion | |||
| Boryspil Raion | |||
| Poltava Oblast | |||
| Pyriatyn Raion | |||
| near Pyriatyn | |||
| Pyriatyn | |||
| Lubny Raion | |||
| near Lubny | |||
| Velyka Bahachka Raion | |||
| Reshetylivka Raion | |||
| near Reshetylivka | |||
| Poltava Raion | |||
| Poltava | |||
| near Dudnykove | |||
| Chutove Raion | |||
| Kharkiv Oblast | |||
| Bohodukhiv Raion | |||
| Kharkiv Raion | |||
| Korotych | near Liubotyn | ||
| north route | |||
| Pisochyn | • Kharkiv ring road (north/south loop) | near Nova Bavaria | |
| near Podvirky | |||
| Lisne | |||
| Horyzont | Kharkiv ring road (north/south loop) | near Rohan | |
| south route | |||
| Pisochyn | • Kharkiv ring road (north/south loop) | near Nova Bavaria | |
| Vysokyi | |||
| Kharkiv Airport | streets of Kharkiv | ||
| Bezliudivka | |||
| Horyzont | Kharkiv ring road (north/south loop) | near Rohan | |
| Chuhuiv Raion | |||
| Chuhuiv military range | |||
| Izium Raion | |||
| Vesele | |||
| Izium | |||
| Donetsk Oblast | |||
| Slovyansk Raion | |||
| Slovyansk | |||
| Semenivka | near Slovyansk | ||
| Slovyansk Raion | |||
| Bakhmut Raion | |||
| Debaltseve | |||
| Debaltseve | end of | ||
| Luhansk Oblast | |||
| Perevalsk Raion | |||
| Lutuhyne Raion | |||
| Luhansk | |||
| Yuvileine | near Luhansk | ||
| Lutuhyne Raion | |||
| Rozkishne | near Luhansk | ||
| Krasnodon | |||
| Izvaryne | border | ||