| Country: | EUR |
| Type: | E |
| Route: | 50 |
| Length Km: | 5100 |
| Direction A: | West |
| Terminus A: | Brest, France |
| Junction: | Paris Paris Metz (south of) Walldorf Nuremberg Prague Prague Trenčín Ternopil Uman Novomoskovsk Debaltseve Rostov-na-Donu |
| Direction B: | East |
| Terminus B: | Makhachkala, Russia |
| Countries: |  France Germany Czech Republic Slovakia Ukraine |
European route E 50 is an A-type east–west connection across the European continent. It connects the key naval port of Brest in France with Makhachkala, on the Caspian Sea in the Russian republic Dagestan.
Half the route comprises highways and the other half provincial roads. The route is some long and runs fully across the European continent.
On its way through Europe it crosses several major European routes, such as:
It is one of the longest E roads on the continent.
Since 2014, parts of the road in eastern Ukraine have been under the control of the separatist Donetsk People's Republic and Lugansk People's Republic. During the 2022 Russian invasion of Ukraine, Russia took direct control of the areas in Donbas.
Gouesnou - Saint-Brieuc - Tramain - Rennes
La Gravelle - Laval - Le Mans
Paris - Reims - Châlons-en-Champagne - Metz - Freyming-Merlebach
Prague (Start of Concurrency with) - Humpolec - Jihlava (End of Concurrency with) - Brno (End of Concurrency with)
Drietoma - Trenčín (Start of Concurrency with)
Žilina (End of Concurrency with) - Martin
Ukraine (Note: since April 2021, M12 and M04 Stryi – Kropyvnytskyi – Debaltseve were combined into M30)[1] [2]Uzhhorod - Mukachevo (End of Concurrency with) - Stryi
Stryi - Ternopil - Khmelnytskyi - Vinnytsia - Uman - Kropyvnytskyi
Kropyvnytskyi - Oleksandriia - Dnipro - Donetsk - Debaltseve
border with Ukraine - Novoshakhtinsk (Start of concurrency with)
Novoshakhtinsk - Rostov-on-Don - Pavlovskaya (End of concurrency with)
Pavlovskaya - Armavir - Mineralnye Vody - Beslan - Makhachkala