Etridiazole Explained

Etridiazole is a fungicide and pesticide used for prevention of pythium ultimum on cotton plants.^[1]

Synthesis

Etridiazole can be synthesised from acetonitrile as follows:

It can also be is produced by the reaction of trichloroacetamidine hydrochloride with trichloromethanesulfenyl chloride, and then with sodium hydroxide in ethanol.^[2]

Reactivity

Etridiazole is stable under normal conditions,^[3] but degrades upon continuous exposure to sunlight,^[4] and is hydrolysed by alkalis.^[5] When heated to decomposition, it emits toxic fumes of hydrogen chloride, sulfur oxides, and nitrogen oxides.^[6]

Safety

Etridiazole has been classified as a Group B2 Probable Human Carcinogen.^[7]

Notes and References

1. News: Applying a Fungicide May Prevent Cotton Replanting. March 27, 2002. Ag Alert.
2. Muller F et al; Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (1999-2012). NY, NY: John Wiley & Sons; Fungicides, Agricultural, 2. Individual Fungicides. Online Posting Date: October 15, 2011
3. Worthing, C.R., S.B. Walker (eds.). The Pesticide Manual - A World Compendium. 7th ed. Lavenham, Suffolk, Great Britain: The Lavenham Press Limited, 1983., p. 252
4. Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 420
5. Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 279
6. Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 1623
7. USEPA Office of Pesticide Programs, Health Effects Division, Science Information Management Branch: "Chemicals Evaluated for Carcinogenic Potential" (April 2006)