HDEP-28 explained

HDEP-28 or ethylnaphthidate is a piperidine based stimulant drug, closely related to ethylphenidate, but with the benzene ring replaced by naphthalene. It is even more closely related to HDMP-28, which acts as a potent serotonin–norepinephrine–dopamine reuptake inhibitor with several times the potency of methylphenidate and a short duration of action.[1] It has been sold as a designer drug since around 2015.[2]

Legality

HDEP-28 was banned in the UK as a Temporary Class Drug from June 2015 following its unapproved sale as a designer drug, alongside 4-Methylmethylphenidate.[3] [4] [5]

See also

Notes and References

  1. Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HM, Nader MA . The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics . The Journal of Pharmacology and Experimental Therapeutics . 307 . 1 . 356–66 . October 2003 . 12954808 . 10.1124/jpet.103.049825 . 5654856 .
  2. Luethi D, Kaeser PJ, Brandt SD, Krähenbühl S, Hoener MC, Liechti ME . Pharmacological profile of methylphenidate-based designer drugs . Neuropharmacology . 134 . Pt A . 133–140 . May 2018 . 28823611 . 10.1016/j.neuropharm.2017.08.020 .
  3. Web site: Methylphenidate-based NPS: A review of the evidence of use and harm. . Advisory Council on the Misuse of Drugs . 31 March 2015 .
  4. Web site: Letter to Mike Penning on methylphenidate-based novel psychoactive substances . Advisory Council on the Misuse of Drugs . 25 June 2015 . 25 June 2015.
  5. Web site: Ministerial response to the Advisory Council on the Misuse of Drugs about 2 new methylphenidate-based substances . Home Office . 25 June 2015 . 25 June 2015.

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