Ethyl bromodifluoroacetate explained

Ethyl bromodifluoroacetate is an ester with the chemical formula . It can be used to introduce the group when synthesising chemical compounds. It is a colorless to yellow liquid. It is an ethyl ester of bromodifluoroacetic acid.

Formation

Ethyl fluorosulfonoxydifluoroacetate can react with sodium bromide (NaBr) to produce ethyl bromodifluoroacetate. And this reaction could happen in the solvent sulfolane. The reactions takes 12 hours at 100 °C with a yield of 31%.

Reactions

Ethyl bromodifluoroacetate, and other similar compounds containing a units can be generated using the Reformatsky reagent with aldehydes and ketones. This yields 2,2-difluoro-3-hydroxy esters. Also ethyl bromdifluoroacetate is considered to be a good compound in generation of compounds and for testing with other organic compounds like lactones, imines and other amino acids.[1]

Notes and References

  1. Sato . Kazuyuki . Tamura . Misato . Tamoto . Kei . Omote . Masaaki . Ando . Akira . Kumadaki . Itsumaro . Michael-type Reaction of Ethyl Bromodifluoroacetate with α,β-Unsaturated Carbonyl Compounds in the Presence of Copper Powder. . Chemical and Pharmaceutical Bulletin . 2000 . 48 . 7 . 1023–1025 . 10.1248/cpb.48.1023 . 10923834.