Ethinylestradiol/megestrol acetate explained
Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.[1] [2] It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet. MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.[3]
See also
- List of combined sex-hormonal preparations § Estrogens and progestogens
Notes and References
- Book: Lara Marks. Sexual Chemistry: A History of the Contraceptive Pill. 2001. Yale University Press. 978-0-300-08943-1. 77–78.
- Mears E . A new type of oral contraceptive . Br Med J . 1 . 5341 . 1318–20 . 1963 . 13934321 . 2123904 . 10.1136/bmj.1.5341.1318.
- El Makhzangy MN, Wynn V, Lawrence DM . Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids . Clinical Endocrinology . 10 . 1 . 39–45 . January 1979 . 571314 . 10.1111/j.1365-2265.1979.tb03031.x . 7262495 .
