Estrone/progesterone/testosterone explained

Estrone/progesterone/testosterone (E1/P4/T), sold under the brand name Tristeron or Tristerone, is an injectable combination medication of estrone (E1), an estrogen, progesterone (P4), a progestogen, and testosterone (T), an androgen/anabolic steroid, which was used in the treatment of functional uterine bleeding in women.^{[1] [2]} It contained 6 mg estrone, 50 mg progesterone, and 25 mg testosterone in microcrystalline aqueous suspension and was administered by intramuscular injection.^{[3] [4]} The medication was manufactured by Wyeth and was marketed by 1951.^[5] It is no longer available.^{[6] [7]}

See also

• List of combined sex-hormonal preparations § Estrogens, progestogens, and androgens

Notes and References

1. Book: Komplexhormon bei Menopause und Hypertonie . Silló G . Hormone und Psyche die Endokrinologie des Alternden Menschen . Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie . Freiburg (Breisgau) . 7–9 March 1957. https://books.google.com/books?id=4NKEBwAAQBAJ&pg=PA55 . Springer-Verlag. 978-3-642-87014-9. 53–57 (55).
2. Greenblatt RB, Barfield WE . Hormonal control of functional uterine bleeding . American Journal of Obstetrics and Gynecology . 63 . 1 . 153–7 . January 1952 . 14894511 . 10.1016/S0002-9378(16)38992-X . 6863371 . The estrogen-progesterone-testosterone combinations used in our studies were supplied by the following pharmaceutical companies: Wyeth, Inc.: Tristerone (6 mg. estrone, 50 mg. progesterone, 25 mg. testosterone).Schering Corporation: Steratrin (1 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testoterone propionate).Sharp and Dohme, Inc.: Lukestra (1.66 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testosterone propionate).Ayerst, McKenna & Harrison Limited: Premarin Injectable, 20 mg. per vial of 5 c.c. .
3. Book: General Practitioner. April 1962. American Academy of General Practice. 109. Estrogen Therapy In an attempt to increase the theoretical effectiveness of testosterone and progesterone, some investigators have added estrogen to the parenteral mixture to form a triad of steroids in an aqueous suspension (Tristerone®)..
4. Book: American Journal of Hospital Pharmacy. 1958. American Society of Hospital Pharmacists.. 114. Tristerone*, Injection (Progesterone, Testosterone, and Estrone) : 25 mg. of microcrystalline progesterone, 25 mg. of microcrystallinefree testosterone, and 6 mg. (60,000 I.U.) of microcrystalline estrone per 1-cc..
5. Book: American Professional Pharmacist. 1951. American Professional Pharmacist, Incorporated. 515. TRISTERONE (Crystalline Progesterone, Testosterone, and Estrone Wyeth).
6. Web site: ? . IBM Watson Health .
7. Web site: Tristeron . Drugs.com .