Estriol dipropionate explained
Estriol dipropionate, or estriol 3,17β-dipropionate, is a synthetic estrogen and estrogen ester – specifically, the C3 and C17β dipropionate ester of estriol – which was first described in 1963 and was never marketed.[1] [2] [3] Following a single intramuscular injection of 6.94 mg estriol dipropionate (equivalent to 5.0 mg estriol) in an oil solution, peak levels of estriol occurred after 0.83 days, an elimination half-life of 12.7 hours was observed, and estriol levels remained elevated for up to 4 days. For comparison, the duration of estriol was much shorter, while that of estriol dihexanoate was much longer.
See also
- List of estrogen esters § Estriol esters
Notes and References
- Book: Kuhnz W, Blade H, Zimmermann H . Pharmacokinetics and Exogenous Natural and Synthetic Estrogens and Antiestrogens. Oettel M, Schillinger E . Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen . https://books.google.com/books?id=wBvyCAAAQBAJ&pg=PA273 . 6 December 2012. Springer Science & Business Media. 978-3-642-60107-1. 273–.
- Tsuneda K, Yamada J, Yasuda K, Mori H . Preparation of some estriol esters . Chemical & Pharmaceutical Bulletin . 11 . 4 . 510–514 . April 1963 . 13994597 . 10.1248/cpb.11.510 . free .
- Heithecker R, Aedo AR, Landgren BM, Cekan SZ . Plasma estriol levels after intramuscular injection of estriol and two of its esters . Hormone Research . 35 . 6 . 234–238 . 1991 . 1819548 . 10.1159/000181911 .
