Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate explained
Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate (EPC/OHPH/NU), tentative brand name Trophobolene or Trophoboline, is an injectable combination medication of estrapronicate (EPC; estradiol nicotinate propionate), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and nandrolone undecanoate (NU), an androgen/anabolic steroid, which was never marketed.[1] [2] It contained 1.3 mg EPC, 80 mg OHPH, and 50 mg NU in oil solution and was administered by intramuscular injection.[3] The medication was developed by Théramex in the mid-to-late 1960s.[4] It was studied for use for a variety of indications, including treatment of coronary insufficiency, growth deficiency, and osteoporosis, as well as hormonal disorders in gonadotropin deficiency.
In contrast to other anabolic steroid-containing preparations, EPC/OHPH/NU reportedly had no masculinizing effects, and its estrogenic component likewise reportedly had no feminizing effects. The nicotinic acid (niacin; vitamin B3) derived from estrapronicate was said to enhance the nutrient, relaxant, and antiadipose effects of the estrogenic component.
The pharmacokinetics of nandrolone undecanoate in this combination preparation have been studied as well as compared to nandrolone alone (Dynabolon).[5]
See also
- List of combined sex-hormonal preparations § Estrogens, progestogens, and androgens
Notes and References
- Book: Polish Endocrinology. 1969. Państwowy Zakład Wydawnuictw Lekarskich (National Institute of Medical Publishing) . 210.
- Vignon G, Pansu D . Le traitement de l'ostéoporose par le trophobolène . The treatment of osteoporosis by trophobolene . fr . Rev Lyon Med . 15 January 1967 . 16 . 1 . 31–8 . 0556-798X . 5595570 .
- Book: Nandrolone . Action QA . Testosterone Congeners—Advances in Research and Application: 2013 Edition: ScholarlyBrief. https://books.google.com/books?id=CR-NH3HzlSkC&pg=PA137 . 21 June 2013. ScholarlyEditions. 978-1-4816-9288-5. 137–. Table 1 Oil based long-acting intramuscular injections products [...] Trophobolene: Estrapronicate 1.3 mg [...] Nandrolone undecanoate 50 mg Hydroxyprogesterone heptanoate 80 mg..
- Book: Kleemann A, Engel JD . Pharmaceutical substances: syntheses, patents, applications. 2001. Thieme. 978-3-13-558404-1. 1397.
- Book: Courtot D, Forichon J, Paris J . Pharmacokinetics of 19-Nortestosterone in Man . 95–110 . Chromatography in Biochemistry, Medicine, and Environmental Research, 1: Proceedings of the 1st International Symposium on Chromatography in Biochemistry, Medicine and Environmental Research, Venice, June 16–17, 1981 . 1983 . Analytical Chemistry Symposia Series . 13 . Elsevier . Amsterdam/Oxford/New York .
