Estradiol valerate/megestrol acetate explained

Estradiol valerate/megestrol acetate (EV/MGA) is a combined injectable contraceptive which was developed in China in the 1980s but was never marketed.^{[1] [2] [3] [4] [5]} It is an aqueous suspension of microcapsules (50–80 μm in diameter) containing 5 mg estradiol valerate (EV) and 15 mg megestrol acetate (MGA). It was also studied at doses of EV ranging from 0.5 to 5 mg and at doses of MGA ranging from 15 to 25 mg.

See also

• List of combined sex-hormonal preparations § Estrogens and progestogens
• Combined injectable birth control § Research

Notes and References

1. Sang GW . Pharmacodynamic effects of once-a-month combined injectable contraceptives . Contraception . 49 . 4 . 361–85 . April 1994 . 8013220 . 10.1016/0010-7824(94)90033-7 .
2. Toppozada MK . Existing once-a-month combined injectable contraceptives . Contraception . 49 . 4 . 293–301 . April 1994 . 8013216 . 10.1016/0010-7824(94)90029-9 .
3. Han ZY, Xiao RQ . Clinical evaluation of intramuscular injection of microencapsulated compound megestrol acetate . Int J Gynaecol Obstet . 22 . 4 . 319–24 . August 1984 . 6152804 . 10.1016/0020-7292(84)90091-2 . 72806071 .
4. Han ZY, Xiao RQ . A follow-up study of the efficacy and safety of injectable microencapsulated megestrol acetate and a discussion on its contraceptive mechanism . Int J Gynaecol Obstet . 23 . 3 . 207–11 . June 1985 . 2865183 . 10.1016/0020-7292(85)90106-7 . 74276439 .
5. Hong Z, Lu B, Wang C . [Determination of megestrol acetate and estradiol valerate in injection of microencapsulated compound megestrol acetate by secondary derivative spectrophotometry] . Chinese . Hua Xi Yi Ke da Xue Xue Bao . 22 . 1 . 87–9 . March 1991 . 1774044 .