Estradiol undecylate/norethisterone enanthate explained

Estradiol undecylate/norethisterone enanthate (EU/NETE) is a combination medication of estradiol undecylate (EU), an estrogen, and norethisterone enanthate (NETE), a progestin, which was developed by Schering for potential use as a combined injectable contraceptive in women but was ultimately never marketed.^{[1] [2] [3] [4] [5] [6]} It contained 5 to 10 mg EU and 50 to 70 mg NETE in oil solution and was intended for use by intramuscular injection at regular intervals. Although never commercialized, EU/NETE was found to be effective and well tolerated.

See also

• Polyestradiol phosphate/medroxyprogesterone acetate
• List of combined sex-hormonal preparations § Estrogens and progestogens

Notes and References

1. Karim M, el-Mahgoub S . Conception control by cyclic injections of norethisterone enanthate and estradiol unducelate . Am. J. Obstet. Gynecol. . 110 . 5 . 740–2 . July 1971 . 5563241 . 10.1016/0002-9378(71)90268-7 .
2. Toppozada MK . Existing once-a-month combined injectable contraceptives . Contraception . 49 . 4 . 293–301 . 1994 . 8013216 . 10.1016/0010-7824(94)90029-9 .
3. Book: Mokhtar K. Toppozada . Monthly Injectable Contraceptives . 93–103 . Alfredo Goldsmith . Mokhtar Toppozada . Long-Acting Contraception . 1983 . 35018604 .
4. Toppozada M . The clinical use of monthly injectable contraceptive preparations . Obstet Gynecol Surv . 32 . 6 . 335–47 . June 1977 . 865726 . 10.1097/00006254-197706000-00001 .
5. Book: Dr. S. S. Kadam. Principles of Medicinal Chemistry Volume 2. July 2007. Pragati Books Pvt. Ltd.. 978-81-85790-03-9. 381–.
6. Newton JR, D'arcangues C, Hall PE . A review of "once-a-month" combined injectable contraceptives . J Obstet Gynaecol (Lahore) . 4 . S1–34 . 1994 . Suppl 1 . 12290848 . 10.3109/01443619409027641.