Estradiol palmitate explained

Estradiol palmitate (brand name Esmopal), or estradiol monopalmitate, also known as estradiol 17β-hexadecanoate, is a naturally occurring^[1] steroidal estrogen and an estrogen ester – specifically, the C17β palmitate ester of estradiol.^[2] It occurs in the body as a very long-lasting metabolite and prohormone of estradiol. The compound has no affinity for the estrogen receptor, requiring transformation into estradiol for its estrogenic activity.^[3] In addition to its endogenous role, estradiol palmitate was formerly used as a fattening agent in chickens under the brand name Esmopal.^{[4] [5] [6] [7] [8]}

See also

• Estradiol stearate
• Estradiol undecylate
• List of estrogen esters § Estradiol esters

Notes and References

1. Hochberg RB, Pahuja SL, Larner JM, Zielinski JE . Estradiol-fatty acid esters. Endogenous long-lived estrogens . Annals of the New York Academy of Sciences . 595 . 1 . 74–92 . 1990 . 2197972 . 10.1111/j.1749-6632.1990.tb34284.x . 19866729 . 1990NYASA.595...74H .
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 898.
3. Janocko L, Larner JM, Hochberg RB . The interaction of C-17 esters of estradiol with the estrogen receptor . Endocrinology . 114 . 4 . 1180–1186 . April 1984 . 6705734 . 10.1210/endo-114-4-1180 .
4. Gerrits RJ . March 1970 . The Influence of Hormones on the Production of Meat. . Sci Teacher . 37 . 3 . 31–34 . 24151460 .
5. Gardiner EE, Newberry RC, Hunt JR . Effect of estradiol-17 beta-monopalmitate on the incidence of sudden death syndrome in male broiler chickens . Poultry Science . 67 . 1 . 156–157 . January 1988 . 3375173 . 10.3382/ps.0670156 . free .
6. Bassila MK, Adams RL, Pratt DE, Stadelman WJ . Effects of Sex, Strain and Estrogens on Quality of Chicken Roasters. Poultry Science. 54. 3. 1975. 696–702. 0032-5791. 10.3382/ps.0540696. free.
7. Moran ET, Etches RJ . Finishing broiler toms using an estradiol 17 beta implant together with a high energy-low protein final feed . Poultry Science . 62 . 6 . 1010–1020 . June 1983 . 6878131 . 10.3382/ps.0621010 . free .
8. Mickelberry WC . Influence of Dietary Fats and Estradiol 17 Beta Monopalmitate Upon the Edible Meat Yield of Roaster Chickens. Poultry Science. 47. 4. 1968. 1254–1257. 0032-5791. 10.3382/ps.0471254. free.