Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate explained

Estradiol diundecylate/hydroxyprogesterone heptanoate/testosterone cyclohexylpropionate (EDU/OHPH/TCHP), sold under the brand name Trioestrine Retard, is an injectable combination medication of estradiol diundecylate (EDU), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and testosterone cyclohexylpropionate (TCHP), an androgen/anabolic steroid.^{[1] [2] [3]} It contained 2.25 mg EDU, 100 mg OHPH, and 67.5 mg TCHP in oil solution, was provided as ampoules, and was administered by intramuscular injection.^{[4] [5]} The medication was manufactured by Roussel and Théramex and was marketed by 1953.^[6] It is no longer available.^{[7] [8]}

See also

• List of combined sex-hormonal preparations § Estrogens, progestogens, and androgens

Notes and References

1. Herschberg AD . [The menopause and the treatment of its disorders by a long-acting multihormone complex: trioestrine lente] . fr . Gazette Médicale de France . 67 . 1987–1996 . October 1960 . 13713782 .
2. Book: Krówczyński L . Extended Release Dosage Forms. 1987. CRC Press. 978-0-8493-4307-0. 13. Hydroxyprogesterone heptanoate + testosterone cyclohexylpropionate + oestradiol undecanoate. Trioestrine-RetardR (Theramex). Oily solution for injection..
3. Book: Kleemann A, Engel J . Pharmaceutical substances: syntheses, patents, applications. 2001. Thieme. 978-3-13-558404-1. 1998.
4. Bordier . Philippe . Cure of fifteen osteoporosis cases by a delayed effect of hormonal association . Semaine des Hopitaux . 39 . 2 . 81–4 . 1963 . 0037-1777 . The patients (females) received intramuscularly, every 10 days for 2-3 months, estradiol diundecyleate 2.25, testosterone cyclohexylpropionate 67.5, and hydroxyprogesterone heptylate 100 mg. ("trioestrine retard"). Their av. calcuria decreased 30.5% (0-69%) and asthenia, anorexia, and muscular activity improved..
5. Book: France. Journal officiel de la République française. 1964. Spécialité dénommée Trioestrine retard Theramex, soluté injectable I. M. : [...] Composition : heptylate d'hydroxy-17 alpha-progestérone, 10 g ; cyclohexyl propionate de testostérone, 10 g ; di-undécylate d'œstradiol, 0,5 g ; excipient Q. S. P. 100 ml (en boîtes de 2 ampoules de 1 ml)..
6. Book: France. Journal officiel de la République française. March 1953. 2564–.
7. Web site: Home . micromedexsolutions.com.
8. Web site: Trioestrine . Drugs.com .