Estradiol dipropionate/hydroxyprogesterone caproate explained

Estradiol dipropionate/hydroxyprogesterone caproate (EDP/OHPC), sold under the brand name EP Hormone Depot, is a combined estrogen–progestogen medication which is used in Japan.^{[1] [2] [3] [4] [5] [6] [7] [8]} It is manufactured by Teikoku Zoki Pharmaceutical Co., Tokyo and contains 1 mg/mL estradiol dipropionate and 50 mg/mL hydroxyprogesterone caproate.

See also

• Estradiol benzoate/hydroxyprogesterone caproate
• Estradiol valerate/hydroxyprogesterone caproate
• List of combined sex-hormonal preparations

Notes and References

1. Web site: Archived copy . 2018-09-17 . 2019-04-07 . https://web.archive.org/web/20190407210353/https://www.drugs.com/international/ep-hormone.html . dead .
2. Kawamura I, Mizota T, Lacey E, Tanaka Y, Manda T, Shimomura K, Kohsaka M . The estrogenic and antiestrogenic activities of droloxifene in human breast cancers . Jpn. J. Pharmacol. . 63 . 1 . 27–34 . September 1993 . 8271528 . 10.1254/jjp.63.27 . free .
3. Asanuma F, Yamada Y, Kawamura E, Lee K, Kobayashi H, Yamada T, Suzuki T, Kubota T . Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R-27 . Folia Microbiol. (Praha) . 43 . 5 . 473–4 . 1998 . 9821299 . 10.1007/BF02820793 . 22732235 .
4. Noguchi M, Tajiri K, Taniya T, Kumaki T, Ashikari A, Miyazaki I . Influence of hormones on proliferation of ER-positive cells and ER-negative cells of human breast cancer (MCF-7) . Oncology . 47 . 1 . 19–24 . 1990 . 2137212 . 10.1159/000226779 . After the transplantation, each mouse received an intramuscular injection of 0.1 ml EP Hormone Depot consisting of 1 mg/ml 17-β-estradiol dipropionate and 50 mg/ml hydroxyprogesterone caproate every week..
5. Kubota T, Oka S, Utsumi T, Inoue S, Kuzuoka M, Suto A, Arisawa Y, Ishibiki K, Abe O . Human breast carcinoma (ZR-75-1) serially transplanted into nude mice--with reference to estradiol dependency and sensitivity to tamoxifen . Jpn J Surg . 19 . 4 . 446–51 . July 1989 . 2810959 . 10.1007/BF02471626 . 23267652 .
6. Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, Okuhara M . FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity . J. Antibiot. . 47 . 3 . 301–10 . March 1994 . 7513682 . 10.7164/antibiotics.47.301 . free .
7. Hori Y, Abe Y, Nishimura M, Goto T, Okuhara M, Kohsaka M . R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. III. Pharmacological properties and antitumor activities . J. Antibiot. . 46 . 7 . 1069–75 . July 1993 . 8360101 . 10.7164/antibiotics.46.1055 . free .
8. Noguchi M, Koyasaki N, Miyazaki I, Mizukami Y . Effects of hormones on tumor growth and immunoreactive insulin-like growth factor-1 of estrogen receptor-positive human breast cancer (MCF-7) transplanted in nude mice . Jpn. J. Cancer Res. . 82 . 11 . 1199–202 . November 1991 . 1752778 . 5918318 . 10.1111/j.1349-7006.1991.tb01780.x .