Estradiol dibutyrate explained

Estradiol dibutyrate (EDBu), or estradiol dibutanoate, is an estrogen medication and an estrogen ester – specifically, a diester of estradiol – which is no longer used.^{[1] [2]} It was a component of Triormon Depositum, a combination formulation of estradiol dibutyrate, testosterone caproate, and hydroxyprogesterone heptanoate which was developed in the 1950s.

See also

• List of estrogen esters § Estradiol esters
• Estradiol dibutyrate/hydroxyprogesterone heptanoate/testosterone caproate

Notes and References

1. Cacciari P . [Experimental research on estradiol dibutyrate] . it . Minerva Ginecol . 12 . 788–9 . August 1960 . 13689684 .
2. Ermiglia G, Valli P . Triormon depositum in climacteric syndrome. Curves of excretion of catabolites and duration of the therapeutic effect . Quaderni Clin. Ostet. E Ginecol. . 12 . 284–93 . 1957 . Triormon depositum (estradiol dibutyrate 3, testosterone caprylate 50, and hydroxyprogesterone heptanoate 30 mg.), administered in castor oil-benzyl benzoate soln. or polyvinylpyrrolidone suspension to 21 women in climacteric, was followed by estradiol, pregnanediol, and 17-keto steroid urinary curves, most with a peak at the 4th day, and approaching starting values at the 8-10th day. The therapeutic efficacy of the drug was satisfactory..