Estradiol dibenzoate explained
| Width: | 250px |
| Cas Number: | 4147-13-1 |
| Pubchem: | 22796092 |
| Chemspiderid: | 18511171 |
| Unii: | 65W00I5071 |
| Synonyms: | EDB; Estradiol 3,17β-dibenzoate; Estra-1,3,5(10)-triene-3,17β-diol 3,17β-dibenzoate |
| Iupac Name: | [(8''R'',9''S'',13''S'',14''S'',17''S'')-3-benzoyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthren-17-yl] benzoate |
| C: | 32 |
| H: | 32 |
| O: | 4 |
| Smiles: | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)C4=CC=CC=C4)CCC5=C3C=CC(=C5)OC(=O)C6=CC=CC=C6 |
| Stdinchi: | 1S/C32H32O4/c1-32-19-18-26-25-15-13-24(35-30(33)21-8-4-2-5-9-21)20-23(25)12-14-27(26)28(32)16-17-29(32)36-31(34)22-10-6-3-7-11-22/h2-11,13,15,20,26-29H,12,14,16-19H2,1H3/t26-,27-,28+,29+,32+/m1/s1 |
| Stdinchikey: | QSEBTTYLHXQXSF-CAHAWPIUSA-N |
Estradiol dibenzoate (EDB), also known as estradiol 3,17β-dibenzoate, is an estrogen ester which was developed in the 1930s and was never marketed.[1] [2] [3] [4] [5] [6] [7] It is the C3 and C17β benzoate diester of estradiol. Estradiol dibenzoate has a longer duration of action than estradiol benzoate (estradiol 3-benzoate) by depot injection.
See also
- List of estrogen esters § Estradiol esters
Notes and References
- Book: Derz FW . 1976 . ChemPRODUCTindex, Volumes 1-2 . De Gruyter . 881– . 978-3-11-002141-7 . 2619908 .
- Parkes AS . Effective Absorption of Hormones . British Medical Journal . 1 . 4024 . 371–373 . February 1938 . 20781252 . 2085798 . 10.1136/bmj.1.4024.371 .
- Parkes AS . Rate of Absorption of Esters of Oestrone and Oestradiol as Determined by Feather Tests . Journal of Endocrinology . March 1942 . 3 . 1 . 288–291 . 0022-0795 . 1479-6805 . 10.1677/joe.0.0030288 .
- Parkes AS . Relative duration of action of various esters of oestrone, oestradiol and oestriol . The Biochemical Journal . 31 . 4 . 579–585 . April 1937 . 16746375 . 1266977 . 10.1042/bj0310579 .
- Miescher K, Scholz C, Tschopp E . The activation of female sex hormones: alpha-Oestradiol and its di-esters . The Biochemical Journal . 32 . 4 . 725–732 . April 1938 . 16746680 . 1264097 . 10.1042/bj0320725 .
- Deanesly R, Sterling Parkes A . Factors influencing the effectiveness of administered hormones . Proceedings of the Royal Society of London. Series B, Biological Sciences . 7 December 1937 . 124 . 836 . 279–298 . 2053-9193 . 10.1098/rspb.1937.0086 . 1937RSPSB.124..279D . 85076285 .
- Book: Vitamins & Hormones . Parkes AS, Emmens CW . Effect of Androgens and Estrogens on Birds . 1944 . 2 . 361–408 . Elsevier . 0083-6729 . 10.1016/S0083-6729(08)60290-3 . 9780127098029 .
