Estradiol benzoate/estradiol phenylpropionate/testosterone propionate/testosterone phenylpropionate/testosterone isocaproate explained

Estradiol benzoate/estradiol phenylpropionate/testosterone propionate/testosterone phenylpropionate/testosterone isocaproate (EB/EPP/TP/TPP/TiC), sold under the brand names Estandron Prolongatum, Lynandron Prolongatum, and Mixogen, was an injectable combination medication of the estrogens estradiol benzoate (EB) and estradiol phenylpropionate (EPP) and the androgens/anabolic steroids testosterone propionate (TP), testosterone phenylpropionate (TPP), and testosterone isocaproate (TiC) which was used in menopausal hormone therapy for women.^{[1] [2]} It was also used to suppress lactation in postpartum women.^[3]

The medication was provided in the form of 1 mL ampoules and 2 mL vials containing 1 mg/mL EB, 4 mg/mL EPP, 20 mg/mL TP, 40 mg/mL TPP, and 40 mg/mL TiC in an oil solution and was administered by intramuscular injection.^{[4] [5]} EB/EPP/TP/TPP/TiC reportedly has a duration of about 14 days.^[6]

Estandron Prolongatum, Lynandron Prolongatum, and Mixogen were all introduced for medical use by 1956.^{[7] [8]} Oral tablet products with the same brand names of Estandron, Lynandron, and Mixogen, containing ethinylestradiol and methyltestosterone, were marketed around the same time, and should not be confused with the injectable products.^[9] Estandron Prolongatum, Lynandron Prolongatum, and Mixogen remained marketed as late as the 1980s.^{[10] [11]} EB/EPP/TP/TPP/TiC appears to no longer be marketed.^{[12] [13] [14]}

See also

• Estradiol benzoate/estradiol phenylpropionate
• List of combined sex-hormonal preparations

Notes and References

1. Book: Hager HH, Kern W, List PH, Roth HJ . Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). 29 July 2013. Springer-Verlag. 978-3-662-25655-8. 141,157,185.
2. Book: Schirren C . Die Sexualhormone . Kimmig J . Therapie der Haut- und Geschlechtskrankheiten. https://books.google.com/books?id=txrUBgAAQBAJ&pg=PA508. 14 March 2013. Springer-Verlag. 978-3-642-94850-3. 508–.
3. Book: Vorherr H . Suppression of Action . The Breast: Morphology, Physiology, and Lactation. https://books.google.com/books?id=wYxirvD2X2IC&pg=PA201. 2 December 2012. Elsevier Science. 978-0-323-15726-1. 201–.
4. Book: Current Medicine and Drugs. 1964. 32. Mixogen Injection is now available in single vials of 2 ml which replace the 1 ml ampoules hitherto supplied. It is widely used for the suppression of lactation and the single 2 ml dose pack is specially designed for obstetric indications..
5. Sharma CP, Chandy T . Influence of steroid hormones on protein-platelet interaction at the blood-polymer interface . Biomaterials . 10 . 9 . 609–616 . November 1989 . 2611310 . 10.1016/0142-9612(89)90115-4 . Mixogen, one 1 ml ampoule contains oestradiol benzoate I.P., 1 mg, oestradiol phenyl propionate, 4 mg, testosterone propionate I.P., 20 mg, testosterone phenyl propionate B.P., 40 mg and testosterone isocaproate B.P., 40 mg. .
6. Book: Ufer J . Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis . Hormone Therapy in Gynecology: Principles and Practice . 5th . de . 1 January 1978 . 978-3110066647 . 924728827 . de Gruyter . 276.
7. Book: Kahr H, Müller HA . Konservative Therapie der Frauenkrankheiten. Behandlung der Menstruationsstörungen. 1956. 1–85. Springer . 10.1007/978-3-7091-5694-0_1. 978-3-7091-5696-4.
8. Neue Spezialitäten. Klinische Wochenschrift. 37. 13. 1959. 719–720. 0023-2173. 10.1007/BF01478227. 13380961.
9. Front Matter. (1953). The British Medical Journal, 2(4835). Retrieved from http://www.jstor.org/stable/20312464
10. Defoort P, Thiery M, Baele G, Clement D, Dhont M . Bromocriptine in an injectable retard form for puerperal lactation suppression: comparison with Estandron prolongatum . Obstetrics and Gynecology . 70 . 6 . 866–869 . December 1987 . 3684122 .
11. Kaiser R . Duration of the climacteric syndrome in women treated by hormonal substitution and in controls . Maturitas . 5 . 3 . 207–213 . March 1984 . 6727694 . 10.1016/0378-5122(84)90054-9 .
12. Web site: Estradiol. Drugs.com.
13. Book: Sweetman SC . Sex hormones and their modulators . Martindale: The Complete Drug Reference . 36th . 2009 . 2100,2124–2125 . Pharmaceutical Press . London . 978-0-85369-840-1.
14. Web site: IBM Watson Health Products: Please Login. www.micromedexsolutions.com.