Estradiol 3-tetrahydropyranyl ether explained

Estradiol 3-tetrahydropyranyl ether is a synthetic estrogen and estrogen ether which was never marketed.^{[1] [2] [3] [4] [5] [6] [7]} It has been reported to possess improved oral activity relative to estradiol. One study in animals found that it had 15 times the oral activity of estradiol.

See also

• List of estrogen esters § Ethers of steroidal estrogens

Notes and References

1. Book: Lemke TL, Williams DA . Foye's Principles of Medicinal Chemistry. 24 January 2012. Lippincott Williams & Wilkins. 978-1-60913-345-0. 1395–.
2. Cross AD, Harrison IT, Kincl FA, Farkas E, Kraay R, Dorfman RI. Steroids CCLXX. Biologically-active labile ethers II. A new group of potent orally-active estrogens. Steroids. 4. 3. 1964. 423–432. 0039-128X. 10.1016/0039-128X(64)90155-2.
3. Kincl FA, Dorfman RI . Antifertility activity of various steroids in the female rat . Journal of Reproduction and Fertility . 10 . 105–113 . August 1965 . 14337800 . 10.1530/jrf.0.0100105 . 32111383 .
4. Locardi G . [Clinical pharmacology and biological characteristics of 3-tetrahydropyranyl ether of 17-beta-estradiol] ]. it . Minerva Ginecologica . 24 . 2 . 70–81 . February 1972 . 4603402 .
5. Plancher G . [On some pharmacobiological characteristics of a new estrogen derivative (3-tetrahydropyranyl ether of 17-beta-estradiol)] . it . Minerva Ginecologica . 23 . 17 . 671–678 . September 1971 . 5131894 .
6. Andreoli C, Lenzi G . [Clinical pharmacological aspects of a new hormone derivative (3-tetrahydropyranyl ether of 17-beta-estradiol)] . it . Minerva Ginecologica . 23 . 18 . 711–724 . September 1971 . 5131179 .
7. Boucheau V, Renaud M, Rolland de Ravel M, Mappus E, Cuilleron CY . Proton and carbon-13 nuclear magnetic resonance spectroscopy of diastereoisomeric 3- and 17 beta-tetrahydropyranyl ether derivatives of estrone and estradiol . Steroids . 55 . 5 . 209–221 . May 1990 . 2163125 . 10.1016/0039-128X(90)90018-7 . 1476967 .