Estradiol 3-glucuronide 17β-sulfate explained

Estradiol 3-glucuronide 17β-sulfate (E2-3G-17S) is an endogenous estrogen conjugate and metabolite of estradiol.^{[1] [2]} It is related to estradiol 3-sulfate and estradiol 17β-glucuronide. Estradiol 3-glucuronide 17β-sulfate has 0.0001% of the relative binding affinity of estradiol for the ERα, one of the two estrogen receptors (ERs).^[3] It shows less than one million-fold lower potency in activating the estrogen receptors relative to estradiol in vitro.^[4]

See also

• Catechol estrogen
• Estrogen conjugate
• Lipoidal estradiol
• List of estrogen esters § Estradiol esters

Notes and References

1. Isobe T, Shiraishi H, Yasuda M, Shinoda A, Suzuki H, Morita M . Determination of estrogens and their conjugates in water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry . J Chromatogr A . 984 . 2 . 195–202 . January 2003 . 12564690 . 10.1016/s0021-9673(02)01851-4 .
2. Katayama M, Matsuda Y, Shimokawa K, Kaneko S . Simultaneous determination of 16 estrogens, dehydroepiandrosterone and their glucuronide and sulfate conjugates in serum using sodium cholate micelle capillary electrophoresis . Biomed. Chromatogr. . 17 . 4 . 263–7 . June 2003 . 12833391 . 10.1002/bmc.236 . free .
3. Durmaz V, Schmidt S, Sabri P, Piechotta C, Weber M . Hands-off linear interaction energy approach to binding mode and affinity estimation of estrogens . J Chem Inf Model . 53 . 10 . 2681–8 . October 2013 . 24063761 . 10.1021/ci400392p .
4. Coldham NG, Dave M, Sivapathasundaram S, McDonnell DP, Connor C, Sauer MJ . Evaluation of a recombinant yeast cell estrogen screening assay . Environ. Health Perspect. . 105 . 7 . 734–42 . July 1997 . 9294720 . 1470103 . 10.1289/ehp.97105734 .