Estradiol/norethisterone acetate explained

Estradiol/norethisterone acetate (E2/NETA), sold under the brand name Activella among others, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis^[1] associated with menopause.^[2] Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. CombiPatch is a combination of estradiol and NETA provided as a transdermal patch.

See also

• Ethinylestradiol/norethisterone acetate
• Ethinylestradiol/norelgestromin
• Estradiol/levonorgestrel
• List of combined sex-hormonal preparations

Notes and References

1. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D'Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito F . 6 . Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study . Journal of Bone and Mineral Research . 17 . 10 . 1904–12 . October 2002 . 12369794 . 10.1359/jbmr.2002.17.10.1904 . 29312298 . free .
2. Web site: CombiPatch (estradiol/norethindrone acetate transdermal system) Prescribing Information . Noven Pharmaceuticals, Inc. . U.S. Food and Drug Administration .