Estradiol/norethisterone explained
Estradiol/norethisterone (E2/NET), tentative brand name Netagen or Netagen 403, was a combination of estradiol (E2), an estrogen, and norethisterone (NET), a progestin, which was studied as a birth control pill to prevent pregnancy in women.[1] [2] [3] [4] [5] It was taken by mouth and contained 4 mg micronized E2 and 3 mg NET per tablet. The medication was developed by Novo Pharmaceuticals in Denmark and was never marketed.
Two related formulations were Netagen 423 (4 mg estradiol, 2 mg estriol, 3 mg norethisterone) and Netasyn (50 μg ethinylestradiol, 3 mg norethisterone), were also studied but never marketed.
See also
Notes and References
- Fruzzetti F, Bitzer J . Review of clinical experience with estradiol in combined oral contraceptives . Contraception . 81 . 1 . 8–15 . January 2010 . 20004267 . 10.1016/j.contraception.2009.08.010 .
- Astedt B, Svanberg L, Jeppsson S, Liedholm P, Rannevik G . The natural oestrogenic hormone oestradiol as a new component of combined oral contraceptives . Br Med J . 1 . 6056 . 269 . January 1977 . 319864 . 1604185 . 10.1136/bmj.1.6056.269 .
- Astedt B, Jeppsson S, Liedholm P, Rannevik G, Svanberg L . Clinical trial of a new oral contraceptive pill containing the natural oestrogen 17 beta-oestradiol . Br J Obstet Gynaecol . 86 . 9 . 732–6 . September 1979 . 387069 . 10.1111/j.1471-0528.1979.tb11276.x . 72299078 .
- Samsioe G, Skryten A, Silfverstolpe G . Oral contraception with a nonalkylated estrogen component. Effects on lipid metabolism . Gynecol. Obstet. Invest. . 15 . 5 . 275–82 . 1983 . 6852647 . 10.1159/000299421 .
- Skouby SO, Jensen BM, Kühl C, Mølsted-Pedersen L, Svenstrup B, Nielsen J . Hormonal contraception in diabetic women: acceptability and influence on diabetes control and ovarian function of a nonalkylated estrogen/progestogen compound . Contraception . 32 . 1 . 23–31 . July 1985 . 4053603 . 10.1016/0010-7824(85)90113-1 .
