Nomegestrol acetate/estradiol explained

Nomegestrol acetate/estradiol (NOMAC-E2), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination medication of nomegestrol acetate, a progestogen, and estradiol, an estrogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy in women.^[1] It is taken by mouth.

Research

Estradiol-containing birth control pills like NOMAC-E2 may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.^[2] This is being studied in the case of NOMAC-E2.^[3]

See also

• List of combined sex-hormonal preparations

External links

• Web site: Estradiol mixture with nomegestrol acetate . U.S. National Library of Medicine . Drug Information Portal .

Notes and References

1. Yang LP, Plosker GL . Nomegestrol acetate/estradiol: in oral contraception . Drugs . 72 . 14 . 1917–28 . October 2012 . 22950535 . 10.2165/11208180-000000000-00000 . 44335732 .
2. Douxfils J, Morimont L, Bouvy C . Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk . Semin Thromb Hemost . October 2020 . 46 . 8 . 872–886 . 33080636 . 10.1055/s-0040-1714140 . 224821517 .
3. Results from large-scale real-world safety study for oral combination contraception pill, Zoely (NOMAC-E2), submitted to European Medicines Agency . Theramex . 27 April 2021 . 9 June 2021.