Estradiol/levonorgestrel explained

Estradiol/levonorgestrel (E2/LNG), sold under brand name Climara Pro, is a combination of estradiol (E2) and levonorgestrel (LNG) which is used in menopausal hormone therapy.^{[1] [2] [3]} It is a 22-cm² transdermal patch containing 4.4 mg estradiol and 1.39 mg levonorgestrel and delivers 45 μg/day estradiol and 15 μg/day levonorgestrel.^[4] E2/LNG was approved for medical use in the United States in 2003.^[5]

See also

• Estradiol/norethisterone acetate
• Ethinylestradiol/norelgestromin
• List of combined sex-hormonal preparations

Notes and References

1. Web site: Climara Pro Prescribing Information . U.S. Food and Drug Administration .
2. Shulman LP . 24659973 . 17Beta-estradiol/levonorgestrel transdermal system for the management of the symptomatic menopausal woman . Expert Opinion on Pharmacotherapy . 5 . 12 . 2559–66 . December 2004 . 15571472 . 10.1517/14656566.5.12.2559 .
3. Dando TM, Perry CM . 72554239 . 17 beta-estradiol/levonorgestrel transdermal system . Treatments in Endocrinology . 3 . 5 . 319–24 . 2004 . 15330679 . 10.2165/00024677-200403050-00005 .
4. Wiedersberg S, Guy RH . Transdermal drug delivery: 30+ years of war and still fighting! . Journal of Controlled Release . 190 . 150–6 . September 2014 . 24852092 . 10.1016/j.jconrel.2014.05.022 . 13842061 .
5. Traynor K . New drug and biological product approvals, 2003 . American Journal of Health-System Pharmacy . 61 . 4 . 338–340 . February 2004 . 15011760 . 10.1093/ajhp/61.4.338 . free .