| Esquièze-Sère | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Esquièze-Sère (65).svg |
| Arrondissement: | Argelès-Gazost |
| Canton: | La Vallée des Gaves |
| Insee: | 65168 |
| Postal Code: | 65120 |
| Mayor: | Patrice Vuillaume[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 42.8767°N -0.0006°W |
| Elevation M: | 700 |
| Elevation Min M: | 659 |
| Elevation Max M: | 1126 |
| Area Km2: | 1.52 |
Esquièze-Sère (in French pronounced as /ɛskjɛz sɛʁ/; Occitan (post 1500);: Esquiesa e Cèra) is a commune in the Hautes-Pyrénées department in south-western France.