| Espiridión Guanco | |
| Office: | Senator of the Philippines from the 8th District |
| Term Start: | October 16, 1916 |
| Term End: | May 2, 1925 |
| Alongside: | Manuel López Hermenegildo Villanueva |
| Predecessor: | office established |
| Successor: | Mariano Yulo |
| Office2: | President pro tempore of the Senate of the Philippines |
| Term Start2: | July 21, 1919 |
| Term End2: | October 27, 1922 |
| Predecessor2: | position established |
| Successor2: | Sergio Osmeña |
| Office3: | Member of the Philippine Assembly from Iloilo's 4th district |
| Term Start3: | October 16, 1909 |
| Term End3: | October 16, 1912 |
| Predecessor3: | Adriano Hernández y Dayot |
| Successor3: | Amando Avanceña |
| Party: | Nacionalista (1909-1925) |
| Birth Date: | 29 December 1874 |
| Birth Place: | Pototan, Iloilo, Captaincy General of the Philippines |
| Death Place: | Hinigaran, Negros Occidental, Philippine Islands |
| Honorific Prefix: | The Honorable |
Espiridión Guanco (29 December 1874 - 2 May 1925) was a Filipino politician during the American occupation.
Guanco was born on 29 December 1874 to Agustin Guanco and Filomena Cordero.
He was first elected to the Philippine Assembly as the representative of the 4th district of Iloilo from 1909 to 1912.[1] Upon the establishment of the Philippine Senate in 1916, he was elected as the first representative of the 8th senatorial district composed of the Negros provinces, Antique and Palawan.[2] During this period, he served as the chamber's first President pro tempore during the 5th Legislature from 1919 to 1922.[3] He served three terms until his death in office on 2 May 1925.